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Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy
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Journal Article
Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy
2020
Overview
Cancer theranostics based on glucose oxidase (GOx)-induced starvation therapy has got more and more attention in cancer management. Herein, GOx armed manganese dioxide nanosheets (denoted as MNS-GOx) were developed as cancer nanotheranostic agent for magnetic resonance (MR)/photoacoustic (PA) dual-modal imaging guided self-oxygenation/hyperthermia dually enhanced starvation cancer therapy. The manganese dioxide nanomaterials with different morphologies (such as nanoflowers, nanosheets and nanowires) were synthesized by a biomimetic approach using melanin as a biotemplate. Afterwards, the manganese dioxide nanosheets (MNS) with two sides and large surface area were selected as the vehicle to carry and deliver GOx. The as-prepared MNS-GOx can perform the circular reaction of glucose oxidation and H
O
decomposition for enhanced starvation therapy. Moreover, the catalytic activity of GOx could be further improved by the hyperthermia of MNS-GOx upon near-infrared laser irradiation. Most intriguingly, MNS-GOx could achieve \"turn-on\" MR imaging and \"turn-off\" PA imaging simultaneously. The theranostic capability of MNS-GOx was evaluated on A375 tumor-bearing mice with all tumor elimination. Our findings integrated molecular imaging and starvation-based synergistic cancer therapy, which provided a new platform for cancer nanotheranostics.
Publisher
Ivyspring International Publisher Pty Ltd,Ivyspring International Publisher
Subject
/ Fever
/ Glucose
/ Glucose Oxidase - pharmacology
/ Hyperthermia, Induced - methods
/ Hypoxia
/ Infrared Rays - therapeutic use
/ Lasers
/ Magnetic Resonance Imaging - methods
/ Mice
/ Multimodal Imaging - methods
/ Neoplasms - diagnostic imaging
/ Oxides
/ Photoacoustic Techniques - methods
/ Photothermal Therapy - methods
/ Starvation - chemically induced
