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Comparative Serum Proteomic Analysis of the Effects of Sodium Selenate on a Mouse Model of Alzheimer’s Disease
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Comparative Serum Proteomic Analysis of the Effects of Sodium Selenate on a Mouse Model of Alzheimer’s Disease
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Journal Article
Comparative Serum Proteomic Analysis of the Effects of Sodium Selenate on a Mouse Model of Alzheimer’s Disease
2019
Overview
Selenium (Se), as a nutritionally essential trace element, has been shown to decrease with age and is closely related to Alzheimer’s disease (AD). To probe the effects of Se on AD pathology, two-dimensional fluorescence difference gel electrophoresis was applied to the serum samples collected from the wild-type (WT) mice and the triple transgenic (PS1M146V/AβPPSwe/TauP301L) AD mice (3xTg-AD), treated with or without sodium selenate in drinking water for 4 months beginning at 2 months of age. Proteomics results revealed 17 differentially expressed proteins between WT and 3xTg-AD mice. It was found that the administration of selenate reversed the alterations of the differentially expressed serum proteins by up-regulating 13 proteins and down-regulating 2 proteins which were reported to be involved in the key pathogenesis of AD, including regulation of Aβ production, lipid metabolism regulation, and anti-inflammation. These results suggested that a dietary supplement with selenate is effective for prevention and treatment of AD, and the mechanism was maybe related to its role in Aβ regulation, lipid metabolism, and anti-inflammation. Moreover, we also presented that α-2 macroglobulin, transthyretin, haptoglobin, alpha-2-HS-glycoprotein, and alpha-1-antitrypsin in the serum can be used to evaluate the effect of selenate on AD pathology.
Publisher
Springer US,Springer Nature B.V
Subject
/ alpha 1-Antitrypsin - metabolism
/ Alzheimer Disease - drug therapy
/ Alzheimer Disease - pathology
/ Animals
/ Biomedical and Life Sciences
/ Gels
/ genetically modified organisms
/ Glycoproteins - antagonists & inhibitors
/ Haptoglobins - antagonists & inhibitors
/ Lipids
/ Mice
/ Oncology
/ Prealbumin - antagonists & inhibitors
/ Pregnancy-Associated alpha 2-Macroglobulins - analysis
/ Pregnancy-Associated alpha 2-Macroglobulins - antagonists & inhibitors
/ Proteins
/ Selenium
/ Serum
/ Sodium
