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Host Responses and Regulation by NFκB Signaling in the Liver and Liver Epithelial Cells Infected with A Novel Tick-borne Bunyavirus
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Host Responses and Regulation by NFκB Signaling in the Liver and Liver Epithelial Cells Infected with A Novel Tick-borne Bunyavirus
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Journal Article
Host Responses and Regulation by NFκB Signaling in the Liver and Liver Epithelial Cells Infected with A Novel Tick-borne Bunyavirus
2015
Overview
Infection in humans by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus transmitted by ticks, is often associated with pronounced liver damage, especially in fatal cases. Little has been known, however, about how liver cells respond to SFTSV and how the response is regulated. In this study we report that proinflammatory cytokines were induced in liver tissues of C57/BL6 mice infected with SFTSV, which may cause tissue necrosis in mice. Human liver epithelial cells were susceptible to SFTSV and antiviral interferon (IFN) and IFN-inducible proteins were induced upon infection. We observed that infection of liver epithelial cells led to significant increases in proinflammatory cytokines and chemokines, including IL-6, RANTES, IP-10 and MIP-3a, which were regulated by NFκB signaling and the activation of NFκB signaling during infection promoted viral replication in liver epithelial cells. Viral nonstructural protein NSs was inhibitory to the induction of IFN-β, but interestingly, NFκB activation was enhanced in the presence of NSs. Therefore, NSs plays dual roles in the suppression of antiviral IFN-β induction as well as the promotion of proinflammatory responses. Our findings provide the first evidence for elucidating host responses and regulation in liver epithelial cells infected by an emerging bunyavirus.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/21
/ 82/29
/ Animals
/ Bunyaviridae Infections - genetics
/ Bunyaviridae Infections - transmission
/ Bunyaviridae Infections - virology
/ Chemokine CCL20 - biosynthesis
/ Chemokine CCL5 - biosynthesis
/ Chemokine CXCL10 - biosynthesis
/ Epithelial Cells - metabolism
/ Host-Pathogen Interactions - genetics
/ Humanities and Social Sciences
/ Humans
/ Interleukin-6 - biosynthesis
/ Mice
/ Orthobunyavirus - pathogenicity
/ Science
