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Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes
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Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes
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Journal Article
Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes
2017
Overview
Chronic inflammation plays a key role in both type 1 and type 2 diabetes. Cytokine and chemokine production within the islets in a diabetic milieu results in β-cell failure and diabetes progression. Identification of targets, which both prevent macrophage activation and infiltration into islets and restore β-cell functionality is essential for effective diabetes therapy. We report that certain Sialic-acid-binding immunoglobulin-like-lectins (siglecs) are expressed in human pancreatic islets in a cell-type specific manner. Siglec-7 was expressed on β-cells and down-regulated in type 1 and type 2 diabetes and in infiltrating activated immune cells. Over-expression of Siglec-7 in diabetic islets reduced cytokines, prevented β-cell dysfunction and apoptosis and reduced recruiting of migrating monocytes. Our data suggest that restoration of human Siglec-7 expression may be a novel therapeutic strategy targeted to both inhibition of immune activation and preservation of β-cell function and survival.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14/63
/ 38
/ 38/109
/ 38/77
/ 38/89
/ 64/60
/ 96/2
/ 96/21
/ 96/31
/ Animals
/ Antigens, Differentiation, Myelomonocytic - genetics
/ Antigens, Differentiation, Myelomonocytic - metabolism
/ Diabetes Mellitus, Type 1 - genetics
/ Diabetes Mellitus, Type 1 - metabolism
/ Diabetes Mellitus, Type 2 - genetics
/ Diabetes Mellitus, Type 2 - metabolism
/ Humanities and Social Sciences
/ Humans
/ Insulin-Secreting Cells - cytology
/ Insulin-Secreting Cells - metabolism
/ Mice
/ Science
