Journal Article

PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study

Nemeth, Adam, Szabo, Dora, Saghy, Eva, Sarszegi, Zsolt, Gyenesei, Attila, Ferdinandy, Peter, Herczeg, Robert, Makkos, Andras, Cziraki, Attila, Reglodi, Dora, Helyes, Zsuzsanna, Tamas, Andrea, Polgar, Beata, Gorbe, Aniko

2021

Overview

Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI.

• Publisher: MDPI AG,MDPI
• Subject: Aged / Angioplasty / Animals / Arrhythmias, Cardiac - blood / Arrhythmias, Cardiac - physiopathology / Arrhythmias, Cardiac - surgery / Biomarkers / Cardiovascular disease / Comorbidity / Female / Glycated Hemoglobin - genetics / Heart attacks / Heart Ventricles - metabolism / Heart Ventricles - pathology / Heart Ventricles - surgery / Humans / Ischemia / Kinases / Male / Middle Aged / Myocardial Infarction - blood / Myocardial Infarction - genetics / Myocardial Infarction - pathology / Myocardial Infarction - surgery / Neuropeptides / Non-ST Elevated Myocardial Infarction - blood / Non-ST Elevated Myocardial Infarction - genetics / Non-ST Elevated Myocardial Infarction - physiopathology / Non-ST Elevated Myocardial Infarction - surgery / Percutaneous Coronary Intervention - adverse effects / Pituitary Adenylate Cyclase-Activating Polypeptide - blood / Pituitary Adenylate Cyclase-Activating Polypeptide - genetics / Plasma / Polypeptides / Proteins / Risk Factors / ST Elevation Myocardial Infarction - blood / ST Elevation Myocardial Infarction - genetics / ST Elevation Myocardial Infarction - pathology / ST Elevation Myocardial Infarction - surgery / Swine / Treatment Outcome / Troponin - blood