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Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients
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Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients
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Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients
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Journal Article
Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients
2024
Overview
Cytomegalovirus (CMV) infection detrimentally influences graft survival in kidney transplant recipients, with the risk primarily determined by recipient and donor serostatus. However, recipient CD8 + T cells play a crucial role in CMV control. The optimal preventive strategy (prophylaxis vs. pre-emptive treatment), particularly for seropositive (intermediate risk) recipients, remains uncertain. We investigated CD8 + T cell subpopulation dynamics and CMV occurrence (DNAemia ≥ 100 IU/mL) in 65 kidney transplant recipients, collecting peripheral blood mononuclear cells before (T1) and 1 year after transplantation (T2). Comparing the two timepoints, we found an increase in granulocyte, monocyte and CD3 + CD8 + T cells numbers, while FoxP3 + CD25 + , LAG-3 + and PD-1 + frequencies were reduced at T2. CMV DNAemia occurred in 33 recipients (55.8%) during the first year. Intermediate risk patients were disproportionally affected by posttransplant CMV ( N = 29/45, 64.4%). Intermediate risk recipients developing CMV after transplantation exhibited lower leukocyte, monocyte, and granulocyte counts and higher FoxP3 + CD25 + frequencies in CD3 + CD8 + T cells pre-transplantation compared to patients staying CMV negative. Pre-transplant FoxP3 + CD25 + in CD3 + CD8 + T cells had the best discriminatory potential for CMV infection prediction within the first year after transplantation (AUC: 0.746). The FoxP3 + CD25 + CD3 + CD8 + T cell subset may aid in selecting intermediate risk kidney transplant recipients for CMV prophylaxis.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Aged
/ CD8-Positive T-Lymphocytes - immunology
/ Cytomegalovirus - immunology
/ Cytomegalovirus Infections - immunology
/ Cytomegalovirus Infections - prevention & control
/ Female
/ Forkhead Transcription Factors - metabolism
/ Humans
/ Interleukin-2 Receptor alpha Subunit - metabolism
/ Kidney Transplantation - adverse effects
/ Kidneys
/ Male
/ Peripheral blood mononuclear cells
/ Risk
/ Software
