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Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
by
Primo, Pasquale
, Marec, František
, Arunkumar, Kallare P.
, Papathanos, Philippos Aris
, Dalíková, Martina
, Perrotta, Maryanna Martina
, Vitagliano, Luigi
, Schmeing, Stephan
, Bourtzis, Kostas
, Meccariello, Angela
, Gravina, Andrea
, Robinson, Mark D.
, Koskinioti, Panagiota
, Ragoussis, Jiannis
, Saccone, Giuseppe
, Salvemini, Marco
, Ippolito, Domenica
, Hall, Brantley
, Gregoriou, Maria-Eleni
, Windbichler, Nikolai
, Giordano, Ennio
, Ruggiero, Alessia
, Scolari, Francesca
, Petrella, Valeria
, Tsoumani, Konstantina T.
, Forlenza, Federica
, Mathiopoulos, Kostas D.
, Tu, Zhijian
, Monti, Simona Maria
, Gucciardino, Michela Anna
in
Animals
/ Ceratitis capitata
/ Ceratitis capitata - genetics
/ Conserved Sequence
/ Embryo, Nonmammalian
/ Embryos
/ Female
/ Females
/ Fruit flies
/ Fruits
/ Genes, Insect
/ Genes, Y-Linked
/ Genetic control
/ Genetic crosses
/ Individualized Instruction
/ Insects
/ Male
/ Male sterility
/ Males
/ Masculinity
/ Pests
/ RNA Interference
/ Sex determination
/ Sex Determination Processes
/ Sex differentiation
/ Y Chromosome - genetics
/ Y chromosomes
2019
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Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
by
Primo, Pasquale
, Marec, František
, Arunkumar, Kallare P.
, Papathanos, Philippos Aris
, Dalíková, Martina
, Perrotta, Maryanna Martina
, Vitagliano, Luigi
, Schmeing, Stephan
, Bourtzis, Kostas
, Meccariello, Angela
, Gravina, Andrea
, Robinson, Mark D.
, Koskinioti, Panagiota
, Ragoussis, Jiannis
, Saccone, Giuseppe
, Salvemini, Marco
, Ippolito, Domenica
, Hall, Brantley
, Gregoriou, Maria-Eleni
, Windbichler, Nikolai
, Giordano, Ennio
, Ruggiero, Alessia
, Scolari, Francesca
, Petrella, Valeria
, Tsoumani, Konstantina T.
, Forlenza, Federica
, Mathiopoulos, Kostas D.
, Tu, Zhijian
, Monti, Simona Maria
, Gucciardino, Michela Anna
in
Animals
/ Ceratitis capitata
/ Ceratitis capitata - genetics
/ Conserved Sequence
/ Embryo, Nonmammalian
/ Embryos
/ Female
/ Females
/ Fruit flies
/ Fruits
/ Genes, Insect
/ Genes, Y-Linked
/ Genetic control
/ Genetic crosses
/ Individualized Instruction
/ Insects
/ Male
/ Male sterility
/ Males
/ Masculinity
/ Pests
/ RNA Interference
/ Sex determination
/ Sex Determination Processes
/ Sex differentiation
/ Y Chromosome - genetics
/ Y chromosomes
2019
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Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
by
Primo, Pasquale
, Marec, František
, Arunkumar, Kallare P.
, Papathanos, Philippos Aris
, Dalíková, Martina
, Perrotta, Maryanna Martina
, Vitagliano, Luigi
, Schmeing, Stephan
, Bourtzis, Kostas
, Meccariello, Angela
, Gravina, Andrea
, Robinson, Mark D.
, Koskinioti, Panagiota
, Ragoussis, Jiannis
, Saccone, Giuseppe
, Salvemini, Marco
, Ippolito, Domenica
, Hall, Brantley
, Gregoriou, Maria-Eleni
, Windbichler, Nikolai
, Giordano, Ennio
, Ruggiero, Alessia
, Scolari, Francesca
, Petrella, Valeria
, Tsoumani, Konstantina T.
, Forlenza, Federica
, Mathiopoulos, Kostas D.
, Tu, Zhijian
, Monti, Simona Maria
, Gucciardino, Michela Anna
in
Animals
/ Ceratitis capitata
/ Ceratitis capitata - genetics
/ Conserved Sequence
/ Embryo, Nonmammalian
/ Embryos
/ Female
/ Females
/ Fruit flies
/ Fruits
/ Genes, Insect
/ Genes, Y-Linked
/ Genetic control
/ Genetic crosses
/ Individualized Instruction
/ Insects
/ Male
/ Male sterility
/ Males
/ Masculinity
/ Pests
/ RNA Interference
/ Sex determination
/ Sex Determination Processes
/ Sex differentiation
/ Y Chromosome - genetics
/ Y chromosomes
2019
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Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
Journal Article
Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
2019
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Overview
In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.
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