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Short androgen receptor poly‐glutamine‐promoted endometrial cancer is associated with benzoapyrene‐mediated aryl hydrocarbon receptor activation
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Short androgen receptor poly‐glutamine‐promoted endometrial cancer is associated with benzoapyrene‐mediated aryl hydrocarbon receptor activation
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Journal Article
Short androgen receptor poly‐glutamine‐promoted endometrial cancer is associated with benzoapyrene‐mediated aryl hydrocarbon receptor activation
2018
Overview
The androgen receptor (AR) poly‐glutamine polymorphism (AR‐Q) was reported to play role in endometrial cancer (EMCA) development, yet controversial. Environmental factors interact with genetic variation have been reported in EMCA. Aerosol toxins, polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP), are EMCA facilitators. This report examined the interplay between AR‐Qs and BaP in EMCA. During analysing patient AR‐Q polymorphism and Aryl hydrocarbon Receptor (AhR) expressions, we found overall survival (OS) benefit is ascending with AR‐Q lengths (5‐year OS of 61.3% in Q length <20 and 88% in Q length >23). And AhR is higher expressed in short AR‐Q tumour compared to that in long AR‐Q patient. In vitro study found androgen‐response element (ARE) activity descends with AR‐Qs length (Q13 > Q25 > Q35), whereas BaP suppresses ARE activities in EMCA cells. Furthermore, AR‐Q13 (but not AR‐Q25, or ‐35) enhances BaP‐induced dioxin‐responsive element (DRE) activity. Lastly, AR‐Q13 exerts higher colony‐forming capacity than other AR‐Qs, and knock‐down AhR abolished AR‐Q13‐mediated colony numbers. This study demonstrated a possible interaction of gene (AR‐Q polymorphism) and environmental toxins (e.g. BaP) to affect cancer progression. A large‐scale epidemiology and public health survey on the interaction of environmental toxin and AR poly‐Q in EMCA is suggested.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Aerosols
/ Aged
/ AhR
/ BaP
/ Cancer
/ Colonies
/ Dioxins
/ Endometrial Neoplasms - genetics
/ Endometrial Neoplasms - pathology
/ Female
/ Humans
/ Original
/ Polycyclic aromatic hydrocarbons
/ Pyrene
/ Receptors, Androgen - genetics
/ Receptors, Androgen - metabolism
/ Receptors, Aryl Hydrocarbon - metabolism
/ Tumors
