Asset Details
Do you wish to reserve the book?
COX Inhibitory and Cytotoxic Naphthoketal-Bearing Polyketides from Sparticola junci
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
COX Inhibitory and Cytotoxic Naphthoketal-Bearing Polyketides from Sparticola junci
Do you wish to request the book?
COX Inhibitory and Cytotoxic Naphthoketal-Bearing Polyketides from Sparticola junci
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
COX Inhibitory and Cytotoxic Naphthoketal-Bearing Polyketides from Sparticola junci
2021
Overview
Axenic fermentation on solid rice of the saprobic fungus Sparticola junci afforded two new highly oxidized naphthalenoid polyketide derivatives, sparticatechol A (1) and sparticolin H (2) along with sparticolin A (3). The structures of 1 and 2 were elucidated on the basis of their NMR and HR-ESIMS spectroscopic data. Assignment of absolute configurations was performed using electronic circular dichroism (ECD) experiments and Time-Dependent Density Functional Theory (TDDFT) calculations. Compounds 1–3 were evaluated for COX inhibitory, antiproliferative, cytotoxic and antimicrobial activities. Compounds 1 and 2 exhibited strong inhibitory activities against COX-1 and COX-2. Molecular docking analysis of 1 conferred favorable binding against COX-2. Sparticolin H (2) and A (3) showed a moderate antiproliferative effect against myelogenous leukemia K-562 cells and weak cytotoxicity against HeLa and mouse fibroblast cells.
Publisher
MDPI AG,MDPI
Subject
/ Anti-Infective Agents - chemistry
/ Anti-Infective Agents - isolation & purification
/ Anti-Infective Agents - pharmacology
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - isolation & purification
/ Antineoplastic Agents - pharmacology
/ Carbon
/ Cell Proliferation - drug effects
/ Cell Survival - drug effects
/ Circular Dichroism - methods
/ Cyclooxygenase Inhibitors - chemistry
/ Cyclooxygenase Inhibitors - isolation & purification
/ Cyclooxygenase Inhibitors - pharmacology
/ Fungi
/ Glycerol
/ Human Umbilical Vein Endothelial Cells
/ Humans
/ Mice
/ Molecular Docking Simulation - methods
