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Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response
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Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response
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Journal Article
Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response
2011
Overview
Therapeutic cancer vaccination is an attractive strategy because it induces T cells of the immune system to recognize and kill tumour cells in cancer patients. However, it remains difficult to generate large numbers of T cells that can recognize the antigens on cancer cells using conventional vaccine carrier systems
1
,
2
. Here we show that
α
-Al
2
O
3
nanoparticles can act as an antigen carrier to reduce the amount of antigen required to activate T cells
in vitro
and
in vivo
. We found that
α
-Al
2
O
3
nanoparticles delivered antigens to autophagosomes in dendritic cells, which then presented the antigens to T cells through autophagy. Immunization of mice with
α
-Al
2
O
3
nanoparticles that are conjugated to either a model tumour antigen or autophagosomes derived from tumour cells resulted in tumour regression. These results suggest that
α
-Al
2
O
3
nanoparticles may be a promising adjuvant in the development of therapeutic cancer vaccines.
Alumina nanoparticles can help induce the immune system to destroy tumours, making them a promising candidate for a therapeutic cancer vaccine.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Aluminum Oxide - pharmacology
/ Animals
/ Antigens
/ Antigens, Neoplasm - immunology
/ Antigens, Neoplasm - pharmacology
/ Cancer
/ Cancer Vaccines - immunology
/ Cancer Vaccines - pharmacology
/ Chemistry and Materials Science
/ Cross-Priming - drug effects
/ Drug Carriers - pharmacology
/ Humans
/ Immunity, Cellular - drug effects
/ Immunity, Cellular - immunology
/ letter
/ Mice
/ Nanotechnology and Microengineering
/ Tumors
/ Vaccines
