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Enzymatic resolution of homoallyllic alcohols using various Rhizopus species
by
Badheka, Lalit P.
, Salvi, Neeta A.
, Chattopadhyay, Subrata
in
1-Aryl-3-buten-1-ols
/ Acetates - metabolism
/ Alcohol
/ alcohols
/ Alcohols - chemistry
/ Alcohols - isolation & purification
/ Alcohols - metabolism
/ Allyl Compounds - chemistry
/ Allyl Compounds - isolation & purification
/ Allyl Compounds - metabolism
/ Biological and medical sciences
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ Hydrology
/ Hydrolysis
/ ketones
/ phenyl-3-buten-1-ol acetate
/ Rhizopus - classification
/ Rhizopus - enzymology
/ Rhizopus - metabolism
/ Rhizopus arrhizus
/ Species Specificity
/ Stereoisomerism
/ Substrate Specificity
2003
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Enzymatic resolution of homoallyllic alcohols using various Rhizopus species
by
Badheka, Lalit P.
, Salvi, Neeta A.
, Chattopadhyay, Subrata
in
1-Aryl-3-buten-1-ols
/ Acetates - metabolism
/ Alcohol
/ alcohols
/ Alcohols - chemistry
/ Alcohols - isolation & purification
/ Alcohols - metabolism
/ Allyl Compounds - chemistry
/ Allyl Compounds - isolation & purification
/ Allyl Compounds - metabolism
/ Biological and medical sciences
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ Hydrology
/ Hydrolysis
/ ketones
/ phenyl-3-buten-1-ol acetate
/ Rhizopus - classification
/ Rhizopus - enzymology
/ Rhizopus - metabolism
/ Rhizopus arrhizus
/ Species Specificity
/ Stereoisomerism
/ Substrate Specificity
2003
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Enzymatic resolution of homoallyllic alcohols using various Rhizopus species
by
Badheka, Lalit P.
, Salvi, Neeta A.
, Chattopadhyay, Subrata
in
1-Aryl-3-buten-1-ols
/ Acetates - metabolism
/ Alcohol
/ alcohols
/ Alcohols - chemistry
/ Alcohols - isolation & purification
/ Alcohols - metabolism
/ Allyl Compounds - chemistry
/ Allyl Compounds - isolation & purification
/ Allyl Compounds - metabolism
/ Biological and medical sciences
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ Hydrology
/ Hydrolysis
/ ketones
/ phenyl-3-buten-1-ol acetate
/ Rhizopus - classification
/ Rhizopus - enzymology
/ Rhizopus - metabolism
/ Rhizopus arrhizus
/ Species Specificity
/ Stereoisomerism
/ Substrate Specificity
2003
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Enzymatic resolution of homoallyllic alcohols using various Rhizopus species
Journal Article
Enzymatic resolution of homoallyllic alcohols using various Rhizopus species
2003
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Overview
The asymmetric resolution of various 1-aryl-3-buten-1-ols via microbial hydrolysis of the corresponding acetates has been investigated using different Rhizopus species. The chosen species, R. arrhizus (wild type), efficiently hydrolyzed 1-phenyl- and 1-para-substituted phenyl-3-buten-1-ol acetates, producing the enantiomerically pure (R)-alcohols with 53-65% yields. Although the antipode acetates were obtained with 9-52% enantiomeric excess, the (S)-alcohols were amenable in >99% enantiomeric excess via a R. arrhizus mediated asymmetric reduction of the corresponding ketones.
Publisher
Springer,Springer Nature B.V
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