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Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
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Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
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Journal Article
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
2023
Overview
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven by chronic T cell antigen receptor (TCR) stimulation over days to weeks. However, we know little about the interplay between CD8
+
T cell function, cell division and epigenetic remodeling within hours of activation. Here, we assessed early CD8
+
T cell differentiation, cell division, chromatin accessibility and transcription in tumor-bearing mice and acutely infected mice. Surprisingly, despite robust activation and proliferation, TST had near complete effector function impairment even before undergoing cell division and had acquired hallmark chromatin accessibility features previously associated with later dysfunction/exhaustion. Moreover, continued tumor/antigen exposure drove progressive epigenetic remodeling, ‘imprinting’ the dysfunctional state. Our study reveals the rapid divergence of T cell fate choice before cell division in the context of tumors versus infection.
Rudloff et al. examine the kinetics of CD8
+
T cell dysfunction/exhaustion. Tumor-specific CD8
+
T cells in the tumor environment exhibit epigenetic modifications within hours, before cell division. The findings suggest a temporal relationship between tumor antigen exposure, chromatin remodeling and dysfunction ‘imprinting’.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
