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Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

by Law, Gordon , Desai, Mehul , Perkovic, Vlado , Erondu, Ngozi , Neal, Bruce , Mahaffey, Kenneth W , Matthews, David R , Fulcher, Greg , Shaw, Wayne , de Zeeuw, Dick

in Aged / Albuminuria - complications / Amputation / Amputation, Surgical - statistics & numerical data / Antidiabetics / Blood glucose / Blood pressure / Body weight / Canagliflozin - adverse effects / Canagliflozin - therapeutic use / Cardiovascular disease / Cardiovascular diseases / Cardiovascular Diseases - epidemiology / Cardiovascular Diseases - mortality / Cardiovascular Diseases - prevention & control / Cerebral infarction / Clinical trials / Diabetes / Diabetes mellitus / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - drug therapy / Diabetes Mellitus, Type 2 - physiopathology / Disease Progression / Drug dosages / FDA approval / Female / Foot - surgery / Glomerular filtration rate / Glomerular Filtration Rate - drug effects / Health risk assessment / Heart attacks / Heart failure / Hospitalization - statistics & numerical data / Humans / Hypoglycemic Agents - adverse effects / Hypoglycemic Agents - therapeutic use / Kidney diseases / Kidney Diseases - etiology / Kidney Diseases - mortality / Kidney transplantation / Male / Medicine / Metatarsus / Middle Aged / Myocardial infarction / Side effects / Sodium / Sodium-glucose cotransporter / Statistical analysis / Stroke

2017

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Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

by Law, Gordon , Desai, Mehul , Perkovic, Vlado , Erondu, Ngozi , Neal, Bruce , Mahaffey, Kenneth W , Matthews, David R , Fulcher, Greg , Shaw, Wayne , de Zeeuw, Dick

2017

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Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

by Law, Gordon , Desai, Mehul , Perkovic, Vlado , Erondu, Ngozi , Neal, Bruce , Mahaffey, Kenneth W , Matthews, David R , Fulcher, Greg , Shaw, Wayne , de Zeeuw, Dick

2017

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Journal Article

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

Law, Gordon,

Desai, Mehul,

Perkovic, Vlado,

Erondu, Ngozi,

Neal, Bruce,

Mahaffey, Kenneth W,

Matthews, David R,

Fulcher, Greg,

Shaw, Wayne,

de Zeeuw, Dick

2017

Overview

In this report of two randomized trials, patients with type 2 diabetes at risk for cardiovascular disease received the sodium–glucose cotransporter 2 inhibitor canagliflozin or placebo and were followed for 188 weeks. Canagliflozin reduced the risk of cardiovascular events.

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Albuminuria - complications

/ Amputation

/ Amputation, Surgical - statistics & numerical data

/ Antidiabetics

/ Blood glucose

/ Blood pressure