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Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

by Schumacher, Jennifer , Elliott, Perry M , Stewart, Michelle , Judge, Daniel P , Schwartz, Jeffrey H , Riley, Steven , Rapezzi, Claudio , Barsdorf, Alexandra I , Hanna, Mazen , Sultan, Marla B , Drachman, Brian M , Witteles, Ronald , Damy, Thibaud , Shah, Sanjiv J , Kristen, Arnt V , Huber, Peter , Maurer, Mathew S , Merlini, Giampaolo , Patterson, Terrell A , Gundapaneni, Balarama , Grogan, Martha , Waddington-Cruz, Marcia

in Administration, Oral / Aged / Aged, 80 and over / Amyloid Neuropathies, Familial - complications / Amyloid Neuropathies, Familial - drug therapy / Amyloidogenesis / Benzoxazoles - adverse effects / Benzoxazoles - therapeutic use / Binding sites / Biopsy / Cardiomyopathies - complications / Cardiomyopathies - drug therapy / Cardiomyopathy / Cardiovascular diseases / Disease Progression / Double-Blind Method / Female / Fibrils / Heart failure / Heart Failure - etiology / Heart Failure - mortality / Hospitalization - statistics & numerical data / Humans / Male / Medical prognosis / Middle Aged / Mortality / Mutation / Myocardium / Patient safety / Patients / Prealbumin - antagonists & inhibitors / Proteins / Quality of Life / Survival Analysis / Transthyretin / Walk Test

2018

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Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

2018

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Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

2018

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Journal Article

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

Schumacher, Jennifer,

Elliott, Perry M,

Stewart, Michelle,

Judge, Daniel P,

Schwartz, Jeffrey H,

Riley, Steven,

Rapezzi, Claudio,

Barsdorf, Alexandra I,

Hanna, Mazen,

Sultan, Marla B,

Drachman, Brian M,

Witteles, Ronald,

Damy, Thibaud,

Shah, Sanjiv J,

Kristen, Arnt V,

Huber, Peter,

Maurer, Mathew S,

Merlini, Giampaolo,

Patterson, Terrell A,

Gundapaneni, Balarama,

Grogan, Martha,

Waddington-Cruz, Marcia

2018

Overview

In this randomized, controlled, phase 3 trial of tafamidis for transthyretin amyloid cardiomyopathy, tafamidis was associated with lower all-cause mortality and lower rates of cardiovascular-related hospitalizations and decline in functional capacity and quality of life.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Aged

/ Aged, 80 and over

/ Amyloid Neuropathies, Familial - complications

/ Amyloid Neuropathies, Familial - drug therapy

/ Amyloidogenesis

/ Benzoxazoles - adverse effects