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Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer

by Gussoni, Gualberto , Vescovo, Giorgio , Verso, Melina , Brenner, Benjamin , Huisman, Menno V , Muñoz, Andres , Becattini, Cecilia , Torbicki, Adam , Agnelli, Giancarlo , Sueiro, Maria R , Campanini, Mauro , Lambert, Catherine , Meyer, Guy , Fontanella, Andrea , Cohen, Alexander , Bauersachs, Rupert , Connors, Jean M

in Administration, Oral / Aged / Anticoagulants / Anticoagulants - administration & dosage / Anticoagulants - adverse effects / Bleeding / Body weight / Cancer / Dalteparin - administration & dosage / Dalteparin - adverse effects / Drug dosages / Embolism / Embolisms / Female / Health risk assessment / Hemorrhage - chemically induced / Hemorrhage - epidemiology / Humans / Hypotheses / Incidence / Injections, Subcutaneous / Intention to Treat Analysis / Male / Middle Aged / Neoplasms - complications / Neoplasms - mortality / Proportional Hazards Models / Pulmonary arteries / Pulmonary Embolism - prevention & control / Pyrazoles - administration & dosage / Pyrazoles - adverse effects / Pyridones - administration & dosage / Pyridones - adverse effects / Secondary Prevention - methods / Single-Blind Method / Thromboembolism / Thrombosis / Veins & arteries / Venous Thromboembolism - drug therapy / Venous Thromboembolism - etiology / Venous Thromboembolism - prevention & control / Venous Thrombosis - prevention & control

2020

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Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer

2020

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Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer

2020

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Journal Article

Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer

Gussoni, Gualberto,

Vescovo, Giorgio,

Verso, Melina,

Brenner, Benjamin,

Huisman, Menno V,

Muñoz, Andres,

Becattini, Cecilia,

Torbicki, Adam,

Agnelli, Giancarlo,

Sueiro, Maria R,

Campanini, Mauro,

Lambert, Catherine,

Meyer, Guy,

Fontanella, Andrea,

Cohen, Alexander,

Bauersachs, Rupert,

Connors, Jean M

2020

Overview

In a randomized trial, oral apixaban was noninferior to a low-molecular-weight heparin, dalteparin, in preventing recurrent venous thromboembolism at 6 months in patients with cancer. The use of apixaban was not associated with a higher risk of major bleeding than dalteparin, even in patients with gastrointestinal cancer.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Aged

/ Anticoagulants

/ Anticoagulants - administration & dosage

/ Anticoagulants - adverse effects

/ Bleeding

/ Body weight