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Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

by Falhammar, Henrik , Reisch, Nicole , Auchus, Richard J. , Kiefer, Florian W. , Sturgeon, Julia , Pivonello, Rosario , Russo, Gianni , Merke, Deborah P. , Chan, Jean L. , Sarafoglou, Kyriakie , Witchel, Selma F. , Srirangalingam, Umasuthan , Cutler, Gordon B. , Isidori, Andrea M. , Hamidi, Oksana , Bancos, Irina , Lin, Vivian H. , Roberts, Eiry , Farber, Robert H. , Rodien, Patrice

in Adrenal Disease / Adrenal Hyperplasia, Congenital - blood / Adrenal Hyperplasia, Congenital - complications / Adrenal Hyperplasia, Congenital - drug therapy / Adult / Adults / Amines - administration & dosage / Amines - adverse effects / Androgens / Androstenedione / Androstenedione - blood / Clinical trials / Corticotropin-releasing hormone / CRF Receptor, Type 1 / Dosage / Dose-Response Relationship, Drug / Double-Blind Method / Drug Therapy, Combination - adverse effects / Drug Therapy, Combination - methods / Endocrinology / Endocrinology General / Fatigue - chemically induced / Fatigue - epidemiology / Female / Genetics / Genetics General / Glucocorticoids / Glucocorticoids - administration & dosage / Glucocorticoids - adverse effects / Growth and Development / Headache - chemically induced / Headache - epidemiology / Hormones / Humans / Hydrocortisone / Hydrocortisone - blood / Hyperplasia / Insulin resistance / Male / Pediatrics / Placebos / Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors / Thiazoles - administration & dosage / Thiazoles - adverse effects / Young Adult

2024

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Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

2024

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Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

2024

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Journal Article

Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

Falhammar, Henrik,

Reisch, Nicole,

Auchus, Richard J.,

Kiefer, Florian W.,

Sturgeon, Julia,

Pivonello, Rosario,

Russo, Gianni,

Merke, Deborah P.,

Chan, Jean L.,

Sarafoglou, Kyriakie,

Witchel, Selma F.,

Srirangalingam, Umasuthan,

Cutler, Gordon B.,

Isidori, Andrea M.,

Hamidi, Oksana,

Bancos, Irina,

Lin, Vivian H.,

Roberts, Eiry,

Farber, Robert H.,

Rodien, Patrice

2024

Overview

In adults with congenital adrenal hyperplasia, crinecerfont, a corticotropin-releasing factor type 1 receptor antagonist, lowered the mean glucocorticoid dose and decreased the mean androstenedione level.

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Publisher

Massachusetts Medical Society

Subject

Adrenal Disease

/ Adrenal Hyperplasia, Congenital - blood

/ Adrenal Hyperplasia, Congenital - complications

/ Adrenal Hyperplasia, Congenital - drug therapy

/ Adult

/ Adults

/ Amines - administration & dosage