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Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

by Bilek, Nicole , Erasmus, Mzwandile , Hokey, David A , Nemes, Elisa , Makhethe, Lebohang , Landry, Bernard , Ryall, Robert , Self, Steven G , Scriba, Thomas J , Rutkowski, Kathryn T , Hopkins, Robert , Ratangee, Frances , Andersen, Peter , Ginsberg, Ann M , Hanekom, Willem A , Gurunathan, Sanjay , Evans, Thomas , Rozot, Virginie , Mulenga, Humphrey , Kromann, Ingrid , Toefy, Asma , Ellis, Ruth D , Geldenhuys, Hennie , Hatherill, Mark , Bekker, Linda-Gail , Mabwe, Simbarashe , DiazGranados, Carlos A

in Adolescent / Adolescents / Antibodies, Bacterial - blood / Antigens / Bacillus Calmette-Guerin vaccine / BCG / BCG Vaccine - adverse effects / BCG Vaccine - immunology / Child / Clinical significance / Disease prevention / Disease transmission / Female / HIV / Human immunodeficiency virus / Humans / Immunization, Secondary / Immunogenicity / Infections / Infectious diseases / Male / Medical research / Mycobacterium tuberculosis - immunology / Neonates / Proportional Hazards Models / Regression analysis / Seroconversion / Tuberculosis / Tuberculosis - diagnosis / Tuberculosis - prevention & control / Tuberculosis - transmission / Tuberculosis Vaccines - adverse effects / Tuberculosis Vaccines - immunology / Vaccine efficacy / Vaccines

2018

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Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

2018

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Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

2018

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Journal Article

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

Bilek, Nicole,

Erasmus, Mzwandile,

Hokey, David A,

Nemes, Elisa,

Makhethe, Lebohang,

Landry, Bernard,

Ryall, Robert,

Self, Steven G,

Scriba, Thomas J,

Rutkowski, Kathryn T,

Hopkins, Robert,

Ratangee, Frances,

Andersen, Peter,

Ginsberg, Ann M,

Hanekom, Willem A,

Gurunathan, Sanjay,

Evans, Thomas,

Rozot, Virginie,

Mulenga, Humphrey,

Kromann, Ingrid,

Toefy, Asma,

Ellis, Ruth D,

Geldenhuys, Hennie,

Hatherill, Mark,

Bekker, Linda-Gail,

Mabwe, Simbarashe,

DiazGranados, Carlos A

2018

Overview

In this phase 2 study, investigators evaluated the potential of two vaccines (H4:IC31 and BCG) to prevent the acquisition of tuberculosis infection and the subsequent development of sustained disease.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adolescents

/ Antibodies, Bacterial - blood

/ Antigens

/ Bacillus Calmette-Guerin vaccine

/ BCG

/ BCG Vaccine - adverse effects