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Dolutegravir or Darunavir in Combination with Zidovudine or Tenofovir to Treat HIV

by Tukamushabe, Phionah , Kaimal, Arvind , Mirembe, Grace , Kambugu, Andrew , Balyegisawa, Apolo , Musaazi, Joseph , Ategeka, Gilbert , Asienzo, Jesca , Castelnuovo, Barbara , Walimbwa, Stephen , Hakim, James , Paton, Nicholas I , Kityo, Cissy , Mugerwa, Henry , Hoppe, Anne , Siika, Abraham , Kiragga, Agnes

in Adolescent / Adult / Adverse events / AIDS / Anti-HIV Agents - administration & dosage / Anti-HIV Agents - adverse effects / Antiretroviral drugs / Antiviral drugs / Child / Confidence intervals / Darunavir - administration & dosage / Darunavir - adverse effects / Drug Resistance / Drug Therapy, Combination / Drugs / Female / Global Health / Heterocyclic Compounds, 3-Ring - administration & dosage / Heterocyclic Compounds, 3-Ring - adverse effects / HIV / HIV Infections - drug therapy / HIV Infections - virology / HIV-1 - isolation & purification / Human immunodeficiency virus / Humans / Infectious Disease / Lamivudine / Male / Middle Aged / Oxazines - administration & dosage / Oxazines - adverse effects / Patients / Piperazines - administration & dosage / Piperazines - adverse effects / Population / Public health / Pyridones - administration & dosage / Pyridones - adverse effects / Reverse Transcriptase Inhibitors - administration & dosage / Reverse Transcriptase Inhibitors - adverse effects / Ritonavir / Statistical analysis / Tenofovir / Tenofovir - administration & dosage / Tuberculosis / Viral Load / Young Adult / Zidovudine / Zidovudine - administration & dosage

2021

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Dolutegravir or Darunavir in Combination with Zidovudine or Tenofovir to Treat HIV

2021

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2021

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Journal Article

Dolutegravir or Darunavir in Combination with Zidovudine or Tenofovir to Treat HIV

Tukamushabe, Phionah,

Kaimal, Arvind,

Mirembe, Grace,

Kambugu, Andrew,

Balyegisawa, Apolo,

Musaazi, Joseph,

Ategeka, Gilbert,

Asienzo, Jesca,

Castelnuovo, Barbara,

Walimbwa, Stephen,

Hakim, James,

Paton, Nicholas I,

Kityo, Cissy,

Mugerwa, Henry,

Hoppe, Anne,

Siika, Abraham,

Kiragga, Agnes

2021

Overview

In this open-label, randomized trial conducted in seven sub-Saharan African countries, patients for whom an initial HIV-1 treatment regimen had failed were switched to a second-line regimen of either dolutegravir or darunavir plus either tenofovir or zidovudine. Dolutegravir was noninferior to darunavir and tenofovir was noninferior to zidovudine in their effects on viral suppression at 48 weeks.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Adverse events

/ AIDS

/ Anti-HIV Agents - administration & dosage

/ Anti-HIV Agents - adverse effects

/ Antiretroviral drugs