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Strong Human Immunodeficiency Virus (HIV)-Specific CD4+ T Cell Responses in a Cohort of Chronically Infected Patients Are Associated with Interruptions in Anti-HIV Chemotherapy
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Strong Human Immunodeficiency Virus (HIV)-Specific CD4+ T Cell Responses in a Cohort of Chronically Infected Patients Are Associated with Interruptions in Anti-HIV Chemotherapy
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Strong Human Immunodeficiency Virus (HIV)-Specific CD4+ T Cell Responses in a Cohort of Chronically Infected Patients Are Associated with Interruptions in Anti-HIV Chemotherapy
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Journal Article
Strong Human Immunodeficiency Virus (HIV)-Specific CD4+ T Cell Responses in a Cohort of Chronically Infected Patients Are Associated with Interruptions in Anti-HIV Chemotherapy
2000
Overview
Virus-specific CD4+ T-helper cell function is important in controlling human immunodeficiency virus (HIV) infection but is impaired in patients with progressive HIV disease. It has been reported that after highly active antiretroviral therapy (HAART), HIV-specific lympho-proliferative responses remain absent, whereas responses to non-HIV microbial antigens are restored. However, in analyzing immune responses in a cohort of chronically infected adults on HAART, we observed strong HIV-specific CD4+ T cell responses of Th-1 phenotype in 11 of 22 patients. The magnitude and frequency of HIV-specific lymphoproliferative responses was strongly associated with previous interruptions in HAART (P = .001). In contrast, the magnitude of CD8+ T cell responses to HIV Gag, Pol, Env, and Nef was similar in patients who had and those who had not interrupted HAART. We conclude that (1) a significant proportion of chronically HIV-infected patients on HAART can generate strong HIV-specific CD4+ and CD8+ T cell immunity and (2) transient interruptions in antiviral treatment may prime or boost HIV-specific CD4+ T-helper responses.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Aged
/ AIDS
/ Anti-HIV Agents - administration & dosage
/ Anti-HIV Agents - therapeutic use
/ Antibodies, Viral - biosynthesis
/ Antigens
/ Biological and medical sciences
/ Drug Administration Schedule
/ Female
/ Gene Products, gag - biosynthesis
/ Highly active antiretroviral therapy
/ HIV
/ HIV 1
/ HIV Infections - drug therapy
/ Humans
/ Immunity
/ Interferon-gamma - metabolism
/ Male
/ T-Lymphocytes, Helper-Inducer - physiology
/ Viral diseases of the lymphoid tissue and the blood. Aids
/ Viruses
