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Endogenous Interleukin-2 Serum Levels in Children Infected with Human Immunodeficiency Virus
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Endogenous Interleukin-2 Serum Levels in Children Infected with Human Immunodeficiency Virus
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Journal Article
Endogenous Interleukin-2 Serum Levels in Children Infected with Human Immunodeficiency Virus
1997
Overview
Levels of interleukin-2 (IL-2) in serum obtained from human immunodeficiency virus (HIV)- infected children at health maintenance visits were measured to characterize endogenous IL-2 responses and to examine the association between these responses and progression of immunosuppression. IL-2 was detectable (level >8.7 pg/mL) in the serum of 28 of 45 HIV-infected children; 42% (19 of 45) had serum IL-2 levels of >39 pg/mL. Children without evidence of immunosuppression (Centers for Disease Control and Prevention Pediatric HIV Classification Immunologic Category 1, n = 15) and children with severe immunosuppression (immunologic category 3, n = 20) had statistically significant lower serum IL-2 levels (mean ± [SD], 134.4 ± 227.3 pg/mL and 18.2 ± 30.3 pg/mL, respectively) than those with moderate immunosuppression (mean ± [SD], 450.5 ± 311.8 pg/ml; immunologic category 2, n = 10) (P < .05, Wilcoxon rank sum test). In those children in whom immunosuppression was evident, decreasing serum IL-2 levels correlated with depletion of CD4+ lymphocytes (r = 0.74), whereas there was an inverse correlation between serum IL-2 levels and CD4+ lymphocyte counts (r=−0.47) in children with no or moderate immunosuppression.
