Asset Details
Do you wish to reserve the book?
Incidence of bacterial blood stream infections in patients with acute GVHD
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Incidence of bacterial blood stream infections in patients with acute GVHD
Do you wish to request the book?
Incidence of bacterial blood stream infections in patients with acute GVHD
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Incidence of bacterial blood stream infections in patients with acute GVHD
2025
Overview
Bacterial bloodstream infections (BSI) can be a substantial contributor to complications of GVHD treatment. The aim of this study was to determine the risk for BSI from neutrophil engraftment through day 100 post transplant in patients with acute GVHD (AGVHD) based on organ involvement and severity. Patients (
n
= 4064) who underwent an allogeneic hematopoietic stem cell transplant (HCT) reported to the CIBMTR registry were analyzed. Grade II-IV AGVHD occurred in 1607 (39.5%) patients and was associated with a greater day-100 incidence of post engraftment BSI than with grade 0/I (24.9 vs. 15.3%). Patients with grade III/IV AGVHD had the highest BSI risk (HR 2.45; 95% CI 1.99–3.0;
p
< 0.0001). Lower GI involvement increased BSI risk (HR 1.54; 95% CI 1.17–2.02;
p
= 0.0019). BSI post-engraftment through day 100 was associated with worse survival (HR 1.64, 95% CI 1.43–1.87;
p
< 0.001) and higher non-relapse mortality (NRM), (HR 2.22; 95% CI 1.91–2.59;
p
< 0.001). Those with stage III/IV GI involvement are at highest risk for BSI. Future studies evaluating novel methods for preventing BSI in these high risk populations are needed to reduce mortality associated with AGVHD.
Highlights
Bacterial blood stream infections are more common in patients with Grade II-IV AGVHD with roughly 25% of these patients developing at least one BSI by day-100.
Patients with grade III/IV AGVHD and those with lower gastrointestinal involvement are at the highest risk for BSI.
Patients who experience a BSI by day 100 have worse survival and over a two-fold higher probability for non-relapse mortality.
Publisher
Nature Publishing Group UK,Nature Publishing Group
