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Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension
by
Franks, Wendy
in
Adult
/ Aged
/ Aged, 80 and over
/ Brinzolamide
/ Cloprostenol - administration & dosage
/ Cloprostenol - adverse effects
/ Cloprostenol - analogs & derivatives
/ Female
/ Glaucoma
/ Glaucoma, Open-Angle - drug therapy
/ Glaucoma, Open-Angle - physiopathology
/ Humans
/ Intraocular pressure
/ Intraocular Pressure - drug effects
/ Male
/ Middle Aged
/ Ocular hypertension
/ Ocular Hypertension - drug therapy
/ Ocular Hypertension - physiopathology
/ Ophthalmic Solutions - administration & dosage
/ Ophthalmology
/ Prostaglandins
/ Sulfonamides - administration & dosage
/ Sulfonamides - adverse effects
/ Thiazines - administration & dosage
/ Thiazines - adverse effects
/ Travoprost
2006
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Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension
by
Franks, Wendy
in
Adult
/ Aged
/ Aged, 80 and over
/ Brinzolamide
/ Cloprostenol - administration & dosage
/ Cloprostenol - adverse effects
/ Cloprostenol - analogs & derivatives
/ Female
/ Glaucoma
/ Glaucoma, Open-Angle - drug therapy
/ Glaucoma, Open-Angle - physiopathology
/ Humans
/ Intraocular pressure
/ Intraocular Pressure - drug effects
/ Male
/ Middle Aged
/ Ocular hypertension
/ Ocular Hypertension - drug therapy
/ Ocular Hypertension - physiopathology
/ Ophthalmic Solutions - administration & dosage
/ Ophthalmology
/ Prostaglandins
/ Sulfonamides - administration & dosage
/ Sulfonamides - adverse effects
/ Thiazines - administration & dosage
/ Thiazines - adverse effects
/ Travoprost
2006
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Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension
by
Franks, Wendy
in
Adult
/ Aged
/ Aged, 80 and over
/ Brinzolamide
/ Cloprostenol - administration & dosage
/ Cloprostenol - adverse effects
/ Cloprostenol - analogs & derivatives
/ Female
/ Glaucoma
/ Glaucoma, Open-Angle - drug therapy
/ Glaucoma, Open-Angle - physiopathology
/ Humans
/ Intraocular pressure
/ Intraocular Pressure - drug effects
/ Male
/ Middle Aged
/ Ocular hypertension
/ Ocular Hypertension - drug therapy
/ Ocular Hypertension - physiopathology
/ Ophthalmic Solutions - administration & dosage
/ Ophthalmology
/ Prostaglandins
/ Sulfonamides - administration & dosage
/ Sulfonamides - adverse effects
/ Thiazines - administration & dosage
/ Thiazines - adverse effects
/ Travoprost
2006
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Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension
Journal Article
Ocular hypotensive efficacy and safety of brinzolamide ophthalmic suspension 1% added to travoprost ophthalmic solution 0.004% therapy in patients with open-angle glaucoma or ocular hypertension
2006
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Overview
ABSTRACT
Objective: The primary objective of this study was to determine if combined travoprost ophthalmic solution 0.004% and brinzolamide ophthalmic suspension 1% therapy is superior in lowering intraocular pressure (IOP) compared to travoprost monotherapy for patients with open angle glaucoma or ocular hypertension. The secondary objective was to measure the percentage of patients achieving IOP levels of 18 mmHg or less.
Study design and methods: Single arm, open-label. Participants: eighty-two patients with inadequate IOP control with travoprost monotherapy. Intervention: the addition of brinzolamide ophthalmic suspension 1% twice daily.
Main outcome measures: The primary endpoint was mean IOP reduction from baseline at 4 and 12 weeks. The percentage of patients who achieved IOP values ≤ 18 mmHg was also measured.
Results: The mean age of the patients was 67 years. Ethnic origin was 92.7% Caucasian, 3.7% Black, 2.4% Asian and 1.2% other. The mean duration of travoprost treatment before the trial started was 30 weeks. Compared to the baseline data (IOP = 22.5 mmHg) with travoprost ophthalmic solution 0.004% monotherapy, IOP was decreased after 4 (n = 78) and 12 (n = 71) weeks of combined travoprost and brinzolamide therapy by an average of 3.9 mmHg (17.4%) and 4.2 mmHg(18.4%), respectively. At baseline 6.3% of patients had an IOP of 18 mmHg or less whereas at 4 and 12 weeks, 53.8% and 60.6% of patients respectively had an IOP of 18 mmHg or less. Common adverse events were mild and included ocular hyperaemia, dysgeusia and eye irritation. Study limitations: this study had a small sample size and was open-label.
Conclusion: Patients receiving combined travoprost ophthalmic solution 0.004% and brinzolamide ophthalmic suspension 1% therapy had lower IOP values compared to those on travoprost monotherapy ( p < 0.0001). Combined therapy resulted in a significantly greater percentage of patients achieving IOPs of 18 mmHg or less ( p < 0.0001).
Publisher
Informa UK Ltd,Taylor & Francis,Informa Healthcare
Subject
/ Aged
/ Cloprostenol - administration & dosage
/ Cloprostenol - adverse effects
/ Cloprostenol - analogs & derivatives
/ Female
/ Glaucoma
/ Glaucoma, Open-Angle - drug therapy
/ Glaucoma, Open-Angle - physiopathology
/ Humans
/ Intraocular Pressure - drug effects
/ Male
/ Ocular Hypertension - drug therapy
/ Ocular Hypertension - physiopathology
/ Ophthalmic Solutions - administration & dosage
/ Sulfonamides - administration & dosage
/ Sulfonamides - adverse effects
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