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EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans
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Journal Article
EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans
2018
Overview
Oral epithelial cells discriminate between pathogenic and non-pathogenic stimuli, and only induce an inflammatory response when they are exposed to high levels of a potentially harmful microorganism. The pattern recognition receptors (PRRs) in epithelial cells that mediate this differential response are poorly understood. Here, we demonstrate that the ephrin type-A receptor 2 (EphA2) is an oral epithelial cell PRR that binds to exposed β-glucans on the surface of the fungal pathogen
Candida albicans
. Binding of
C. albicans
to EphA2 on oral epithelial cells activates signal transducer and activator of transcription 3 and mitogen-activated protein kinase signalling in an inoculum-dependent manner, and is required for induction of a proinflammatory and antifungal response.
EphA2
–/–
mice have impaired inflammatory responses and reduced interleukin-17 signalling during oropharyngeal candidiasis, resulting in more severe disease. Our study reveals that EphA2 functions as a PRR for β-glucans that senses epithelial cell fungal burden and is required for the maximal mucosal inflammatory response to
C. albicans
.
How the oral epithelium discriminates pathogens from commensals is unclear. Ephrin A2 is now shown to bind exposed β-glucans on the surface of the fungal pathogen
Candida albicans
, which is required to mount a proinflammatory and antifungal response.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Candida albicans - growth & development
/ Candida albicans - metabolism
/ Candidiasis, Oral - metabolism
/ Candidiasis, Oral - pathology
/ Epithelial Cells - metabolism
/ Epithelial Cells - microbiology
/ ErbB Receptors - antagonists & inhibitors
/ Glucans
/ Inflammation Mediators - analysis
/ Inoculum
/ Kinases
/ Male
/ Mice
/ Mucosa
/ Pattern recognition receptors
/ Receptor, EphA2 - antagonists & inhibitors
/ Receptor, EphA2 - deficiency
/ Receptor, EphA2 - metabolism
/ Receptors, Pattern Recognition - antagonists & inhibitors
/ Receptors, Pattern Recognition - deficiency
/ Receptors, Pattern Recognition - metabolism
/ STAT3 Transcription Factor - metabolism
/ Virology
/ β-Glucan
