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Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse
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Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse
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Journal Article
Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse
2025
Overview
The authors present a child with a rare case of unilateral pseudo-hypopyon and raised intraocular pressure as the only manifestation of acute lymphoblastic leukemia recurrence. This was treated with intravitreal methotrexate and chimeric antigen receptor T-cell therapy (CAR-T) with subsequent remission. This case demonstrates intravitreal methotrexate is a safe and effective adjunct to use with CAR-T therapy for relapsing acute lymphoblastic leukemia with ocular involvement. Further research should be sought on both CAR-T therapy and intravitreal methotrexate for acute lymphoblastic leukemia with ocular involvement. [J Pediatr Ophthalmol Strabismus. 2025;62(2):e18–e21.]
Publisher
SLACK Incorporated,Slack, Inc,SLACK INCORPORATED
Subject
/ Anterior Eye Segment - pathology
/ Antigens
/ Antimetabolites, Antineoplastic - administration & dosage
/ Cancer
/ Child
/ Cornea
/ Diseases
/ Female
/ Humans
/ Immunotherapy, Adoptive - methods
/ Leukemia
/ Male
/ Methotrexate - administration & dosage
/ Neoplasm Recurrence, Local - therapy
/ Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
/ Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
/ Relapse
/ T cells
