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Increases in Ocular Syphilis—North Carolina, 2014–2015
by
Samoff, Erika
, Cope, Anna Barry
, Williams, Charnetta
, Markowitz, Lauri
, Liu, Gui
, Fleischauer, Aaron T.
, Rinsky, Jessica L.
, Peterman, Thomas A.
, Oliver, Sara E.
, Hawks, Stephanie
in
Adult
/ Aged
/ ARTICLES AND COMMENTARIES
/ Bacteria
/ Blindness
/ Demographics
/ Epidemiology
/ Etiology
/ Eye Infections, Bacterial - epidemiology
/ Female
/ HIV
/ Human behavior
/ Human immunodeficiency virus
/ Humans
/ Male
/ Medical records
/ Middle Aged
/ North Carolina - epidemiology
/ Patients
/ Risk Factors
/ Sexually transmitted diseases
/ STD
/ Syphilis
/ Syphilis - epidemiology
/ Treponema pallidum
/ Viruses
/ Vision
/ Young Adult
2017
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Increases in Ocular Syphilis—North Carolina, 2014–2015
by
Samoff, Erika
, Cope, Anna Barry
, Williams, Charnetta
, Markowitz, Lauri
, Liu, Gui
, Fleischauer, Aaron T.
, Rinsky, Jessica L.
, Peterman, Thomas A.
, Oliver, Sara E.
, Hawks, Stephanie
in
Adult
/ Aged
/ ARTICLES AND COMMENTARIES
/ Bacteria
/ Blindness
/ Demographics
/ Epidemiology
/ Etiology
/ Eye Infections, Bacterial - epidemiology
/ Female
/ HIV
/ Human behavior
/ Human immunodeficiency virus
/ Humans
/ Male
/ Medical records
/ Middle Aged
/ North Carolina - epidemiology
/ Patients
/ Risk Factors
/ Sexually transmitted diseases
/ STD
/ Syphilis
/ Syphilis - epidemiology
/ Treponema pallidum
/ Viruses
/ Vision
/ Young Adult
2017
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Increases in Ocular Syphilis—North Carolina, 2014–2015
by
Samoff, Erika
, Cope, Anna Barry
, Williams, Charnetta
, Markowitz, Lauri
, Liu, Gui
, Fleischauer, Aaron T.
, Rinsky, Jessica L.
, Peterman, Thomas A.
, Oliver, Sara E.
, Hawks, Stephanie
in
Adult
/ Aged
/ ARTICLES AND COMMENTARIES
/ Bacteria
/ Blindness
/ Demographics
/ Epidemiology
/ Etiology
/ Eye Infections, Bacterial - epidemiology
/ Female
/ HIV
/ Human behavior
/ Human immunodeficiency virus
/ Humans
/ Male
/ Medical records
/ Middle Aged
/ North Carolina - epidemiology
/ Patients
/ Risk Factors
/ Sexually transmitted diseases
/ STD
/ Syphilis
/ Syphilis - epidemiology
/ Treponema pallidum
/ Viruses
/ Vision
/ Young Adult
2017
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Journal Article
Increases in Ocular Syphilis—North Carolina, 2014–2015
2017
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Overview
Ocular syphilis is an inflammatory eye disease due to Treponema pallidum infection. In the United States, syphilis rates have increased since 2000; clusters of ocular syphilis were reported in 2015. We investigated ocular syphilis in North Carolina to describe the epidemiology and clinical course of disease.
We reviewed syphilis cases reported to North Carolina during 2014-2015 and abstracted information from health department interviews for cases with ocular symptoms and no other defined etiology. To assess duration and severity of ocular symptoms, we also reviewed medical records and conducted structured interviews. We compared the prevalence of ocular manifestations among reported syphilis cases by demographic and clinical characteristics.
Among 4232 syphilis patients, 63 (1.5%) had ocular syphilis: 21 in 2014 and 42 in 2015, a 100% increase. Total syphilis cases increased 35% through 2015. No patient with ocular syphilis named another ocular syphilis patient as a sex partner. Patients presented in all syphilis stages; 24 (38%) were diagnosed in primary or secondary syphilis. Ocular manifestations were more prevalent among syphilis patients who were male, aged ≥40 years, white, and infected with human immunodeficiency virus. No risk behaviors were associated with ocular syphilis. Among 39 interviewed patients, 34 (87%) reported reduced vision during infection; 12 (31%) reported residual visual symptoms posttreatment.
In North Carolina, ocular syphilis increased from 2014 to 2015 and may be due to increased recognition of ocular manifestations, or a true increase in ocular syphilis. Many ocular syphilis patients experienced vision loss; however, most improved posttreatment.
Publisher
Oxford University Press
Subject
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