Asset Details
Do you wish to reserve the book?
The role of the immune system in progressive multifocal leukoencephalopathy: a comparative analysis of two cases following autologous and allogeneic hematopoietic stem cell transplantation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The role of the immune system in progressive multifocal leukoencephalopathy: a comparative analysis of two cases following autologous and allogeneic hematopoietic stem cell transplantation
Do you wish to request the book?
The role of the immune system in progressive multifocal leukoencephalopathy: a comparative analysis of two cases following autologous and allogeneic hematopoietic stem cell transplantation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The role of the immune system in progressive multifocal leukoencephalopathy: a comparative analysis of two cases following autologous and allogeneic hematopoietic stem cell transplantation
2025
Overview
Progressive multifocal leukoencephalopathy (PML) is a rare, subacute demyelinating disorder of the central nervous system (CNS) caused by the JCV. In immunosuppressed hosts, PML is caused by reactivation of a latent infection rather than primary exposure. Hematological patients, particularly post-transplant, presenting with worsening neurological symptoms should promptly consider PML in the differential diagnosis. The rarity of PML after autologous or allogeneic hematopoietic stem cell transplantation (HSCT) and the absence of a universally effective therapy represents a clinical challenge. Here, we present two cases of PML developed after autologous and allogeneic HSCT, with completely different outcomes dependent on the patients’ clinical backgrounds and the level of immune system competence which is the key factor in determining either the onset or viral clearance of the infection.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Biopsy
/ Consent
/ Female
/ Hematopoietic Stem Cell Transplantation - adverse effects
/ Humans
/ Leukoencephalopathy, Progressive Multifocal - diagnosis
/ Leukoencephalopathy, Progressive Multifocal - etiology
/ Leukoencephalopathy, Progressive Multifocal - immunology
/ Lymphoma
/ Male
/ Medicine
/ Oncology
/ Steroids
/ Transplantation, Autologous - adverse effects
