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Multifunctional rhodamine B appended ROMP derived fluorescent probe detects Al3+ and selectively labels lysosomes in live cells
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Multifunctional rhodamine B appended ROMP derived fluorescent probe detects Al3+ and selectively labels lysosomes in live cells
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Journal Article
Multifunctional rhodamine B appended ROMP derived fluorescent probe detects Al3+ and selectively labels lysosomes in live cells
2020
Overview
There a few reports of rhodamine-based fluorescent sensors for selective detection of only Al
3+
, due to the challenge of identifying a suitable ligand for binding Al
3+
ion. The use of fluorophore moieties appended to a polymer backbone for sensing applications is far from mature. Here, we report a new fluorescent probe/monomer
4
and its ROMP derived polymer
P
for specific detection of Al
3+
ions. Both monomer
4
and its polymer
P
exhibit high selectivity toward only Al
3+
with no interference from other metal ions, having a limit detection of 0.5 and 2.1 µM, respectively. The reversible recognition of monomer
4
and
P
for Al
3+
was also proved in presence of Na
2
EDTA by both UV–Vis and fluorometric titration. The experimental data indicates the behavior of
4
and
P
toward Al
3+
is pH independent in medium conditions. In addition, the switch-on luminescence response of
4
at acidic pH (0 < 5.0), allowed us to specifically stain lysosomes (pH ~ 4.5–5.0) in live cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
