Asset Details
Do you wish to reserve the book?
Clinical characteristics of 41 children with hypertrophic cardiomyopathy: A single-center retrospective study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Clinical characteristics of 41 children with hypertrophic cardiomyopathy: A single-center retrospective study
Do you wish to request the book?
Clinical characteristics of 41 children with hypertrophic cardiomyopathy: A single-center retrospective study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Clinical characteristics of 41 children with hypertrophic cardiomyopathy: A single-center retrospective study
2025
Overview
Objective
To analyze the clinical characteristics, etiological composition, genetic variations, and survival outcomes of children with hypertrophic cardiomyopathy.
Materials and methods
This retrospective study included 41 pediatric patients diagnosed with hypertrophic cardiomyopathy at The First Affiliated Hospital of Guangxi Medical University from 2013 to 2024. Clinical data were reviewed, including symptoms, echocardiography, electrocardiography, genetic testing, and follow-up outcomes. Comparisons were made between patients with primary and secondary hypertrophic cardiomyopathy.
Results
Among the 41 patients, 27 were men and 14 were women, with a median age at onset of 4 years and 3 months. Genetic testing was performed in 24 cases, identifying 13 cases of primary hypertrophic cardiomyopathy and 11 cases of secondary hypertrophic cardiomyopathy, most commonly associated with Noonan syndrome. The most frequent symptoms were fatigue (28.95%) and dyspnea (23.68%). Common pathogenic genes in primary hypertrophic cardiomyopathy included MYH7 and MYBPC3. Echocardiography revealed asymmetric interventricular septal hypertrophy in 61.0% of cases and left ventricular outflow tract obstruction in 22.0%. No statistically significant differences were observed between primary and secondary hypertrophic cardiomyopathy groups in clinical manifestations or imaging findings. During follow-up, seven patients died. Kaplan–Meier analysis showed a median survival time of 61.4 months, with no significant difference in survival between the two groups.
Conclusion
Pediatric hypertrophic cardiomyopathy demonstrates substantial heterogeneity in clinical presentation and genetic background. Enhanced early screening and genetic testing may improve diagnostic accuracy and facilitate individualized management strategies.
Publisher
SAGE Publications,Sage Publications Ltd,SAGE Publishing
