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The effect of nasal continuous positive airway pressure on the symptoms of Gulf War illness
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Journal Article
The effect of nasal continuous positive airway pressure on the symptoms of Gulf War illness
2011
Overview
Purpose
We performed a pilot study to determine whether nasal continuous positive airway pressure (CPAP) alleviates the symptoms of veterans with Gulf War illness (GWI) and sleep disordered breathing (SDB).
Methods
Eighteen male veterans with GWI and SDB recruited by advertisement, participated in a randomized, single-masked, sham-controlled treatment trial. Participants received 3 weeks of treatment during sleep with either therapeutic nasal CPAP or sham nasal CPAP. Using validated questionnaires, pain, fatigue, cognitive function, sleep disturbance, and general health were assessed by self-report before and after treatment. One of the participants assigned to therapeutic CPAP was excluded from the trial before starting treatment, leaving 17 participants.
Results
Compared to the nine sham nasal CPAP recipients, the eight participants receiving therapeutic nasal CPAP experienced improvements in pain (34%;
p
= 0.0008), fatigue (38%;
p
= 0.0002), cognitive function (33%;
p
= 0.004), sleep quality (41%;
p
= 0.0003), physical health (34%;
p
= 0.0003), and mental health (16%;
p
= 0.03).
Conclusions
Our findings in this pilot study suggest that nasal CPAP may greatly improve symptoms in veterans with GWI and SDB.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Biological and medical sciences
/ Cerebrospinal fluid. Meninges. Spinal cord
/ Continuous Positive Airway Pressure
/ Fatigue
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Male
/ Medicine
/ Nasal continuous positive airway pressure
/ Nervous system (semeiology, syndromes)
/ Pain
/ Persian Gulf Syndrome - diagnosis
/ Persian Gulf Syndrome - therapy
/ Pneumology/Respiratory System
/ Sleep
/ Sleep Apnea Syndromes - diagnosis
/ Sleep Apnea Syndromes - therapy
/ Sleep Apnea, Obstructive - diagnosis
/ Sleep Apnea, Obstructive - therapy
/ Symptoms
/ Therapy
/ Vertebrates: nervous system and sense organs
/ Veterans
