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Dental Fluorosis : Variability among Different Inbred Mouse Strains
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Journal Article
Dental Fluorosis : Variability among Different Inbred Mouse Strains
2002
Overview
Concurrent with the decline in dental caries has been an increase in the prevalence
of dental fluorosis, a side-effect of exposure to greater than optimal levels of
fluoride during amelogenesis. The mechanisms that underlie the pathogenesis of dental
fluorosis are not known. We hypothesize that genetic determinants influence an
individual’s susceptibility or resistance to develop dental fluorosis. We tested this
hypothesis using a mouse model system (continuous eruption of the incisors) where
genotype, age, gender, food, housing, and drinking water fluoride level can be
rigorously controlled. Examination of 12 inbred strains of mice showed differences in
dental fluorosis susceptibility/resistance. The A/J mouse strain is highly
susceptible, with a rapid onset and severe development of dental fluorosis compared
with that in the other strains tested, whereas the 129P3/J mouse strain is least
affected, with minimal dental fluorosis. These observations support the contribution
of a genetic component in the pathogenesis of dental fluorosis.
Publisher
SAGE Publications
