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Effect of circadian rhythm disruption on benign prostatic hyperplasia in rats
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Effect of circadian rhythm disruption on benign prostatic hyperplasia in rats
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Journal Article
Effect of circadian rhythm disruption on benign prostatic hyperplasia in rats
2025
Overview
Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Disrupted circadian rhythms (CRD) can directly influence aging, inflammation, metabolic syndrome, and hormonal changes—all of which are closely linked to BPH. This study aimed to investigate whether CRD accelerates prostatic hyperplasia in rats. Twenty male Sprague-Dawley (SD) rats were divided into two batches. A BPH model was established using mixed slow-release pellets of testosterone (T) and estradiol (E2). CRD was induced by continuous light exposure (Cle), while a 12-hour light/12-hour dark cycle defined the control (Con) group.
Publisher
PeerJ. Ltd,PeerJ, Inc,PeerJ Inc
Subject
/ Animals
/ Benign prostatic hyperplasia
/ Chronobiology Disorders - complications
/ Circadian Rhythm - physiology
/ Estrogen
/ Genes
/ Genomics
/ Light
/ Male
/ Prostate
/ Prostatic Hyperplasia - etiology
/ Prostatic Hyperplasia - genetics
/ Prostatic Hyperplasia - pathology
/ Prostatic Hyperplasia - physiopathology
/ Protein-protein interactions
/ Rats
/ RNA
