Journal Article

Effects of Laurocerasus Officinalis Roem (Cherry Laurel) on Cognitive Function and Neurobiochemical Pathways in a Streptozotocin-Induced Nontransgenic Alzheimer’s Disease Model

Uzun, Hafize, Ozsoy, Fulya, Sayili, Ugurcan, Yanar, Karolin, Atukeren, Pinar

2026

Overview

Background: This study investigated the effects of Laurocerasus officinalis Roem (cherry laurel; CL), a traditionally consumed fruit, on cognitive performance and selected neurobiochemical and metabolic pathways in a nontransgenic streptozotocin (STZ)-induced Alzheimer’s disease (i.c.v. STZ) model and an STZ-induced type 2 diabetes mellitus (T2DM; i.p. STZ) model. Method: Fifty-seven adult male Sprague–Dawley rats were allocated to control, T2DM, and Alzheimer (ALZ) model groups, with subgroup interventions including CL supplementation and, in the T2DM model, metformin as a comparator. Spatial learning and memory were assessed using the Morris Water Maze. Serum and brain tissue levels of GSK3-β, glutathione (GSH), interleukin-1 (IL-1), GLUT4, GLP-1, β-amyloid (Aβ), and acetylcholinesterase (AChE) were quantified. Results: Serum GSK3-β levels did not differ significantly between groups, whereas brain tissue GSK3-β showed significant between-group differences. CL increased GSH levels in both models, with significant elevations in serum and brain tissue GSH in the ALZ model following CL administration; in the T2DM model, GSH increased after both CL and metformin. In the ALZ model, CL was associated with decreased serum Aβ and AChE levels and improved Morris Water Maze performance, reflected by reduced escape latencies. Conclusions: CL supplementation was associated with antioxidant enhancement and modulation of amyloid- and cholinergic-related measures, alongside improved spatial learning performance in the STZ-induced nontransgenic ALZ model. In addition, CL reduced blood glucose in the T2DM model. Given the likely contribution of fruit phytochemicals (including total phenolics), further studies are warranted to better define the bioactive composition and mechanisms underlying these effects.

• Publisher: MDPI AG,Multidisciplinary Digital Publishing Institute (MDPI)
• Subject: Alzheimer Disease - chemically induced / Alzheimer Disease - drug therapy / Alzheimer Disease - metabolism / Alzheimer Disease - psychology / Alzheimer's disease / Analysis / Animal cognition / Animals / Antioxidants / Blood sugar / Brain - drug effects / Brain - metabolism / Cerebrospinal fluid / Chemical properties / Cognition - drug effects / Cognitive ability / Diabetes / Diabetes Mellitus, Experimental - chemically induced / Diabetes Mellitus, Experimental - drug therapy / Diabetes Mellitus, Type 2 - drug therapy / Diet therapy / Dietary supplements / Disease Models, Animal / Diseases / Enzymes / Ethylenediaminetetraacetic acid / Flavonoids / Fruit / Fruit - chemistry / Fruits / Glucose / Glutathione - metabolism / Glycogen Synthase Kinase 3 beta - blood / Glycogen Synthase Kinase 3 beta - metabolism / Health aspects / Illinois / Insulin resistance / Interleukins / Kinases / Laboratory animals / Male / Materia medica, Vegetable / Maze Learning - drug effects / Metabolism / Metformin - pharmacology / Peptides / Phytochemicals / Plant extracts / Plant Extracts - pharmacology / Rats / Rats, Sprague-Dawley / Streptozocin / Toxicity / Turkey / Type 2 diabetes