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Endothelin-B receptors and ventricular arrhythmogenesis in the rat model of acute myocardial infarction
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Endothelin-B receptors and ventricular arrhythmogenesis in the rat model of acute myocardial infarction
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Journal Article
Endothelin-B receptors and ventricular arrhythmogenesis in the rat model of acute myocardial infarction
2010
Overview
The arrhythmogenic effects of endothelin-1 (ET-1) are mediated via ETA-receptors, but the role of ETB-receptors is unclear. We examined the pathophysiologic role of ETB-receptors on ventricular tachyarrhythmias (VT/VF) during myocardial infarction (MI). MI was induced by coronary ligation in two animal groups, namely in wild-type (
n
= 63) and in ETB-receptor-deficient (
n
= 61) rats. Using a telemetry recorder, VT/VF episodes were evaluated during phase I (the 1st hour) and phase II (2–24 h) post-MI, with and without prior β-blockade. Action potential duration at 90% repolarization (APD90) was measured from monophasic epicardial recordings and indices of sympathetic activation were assessed using fast-Fourier analysis of heart rate variability. Serum epinephrine and norepinephrine were measured with radioimmunoassay. MI size was similar in the two groups. There was a marked temporal variation in VT/VF duration; during phase I, it was
higher
(
p
= 0.0087) in ETB-deficient (1,519 ± 421 s) than in wild-type (190 ± 34 s) rats, but tended (
p
= 0.086) to be
lower
in ETB-deficient (4.2 ± 2.0 s) than in wild-type (27.7 ± 8.0 s) rats during phase II. Overall, the severity of VT/VF was greater in ETB-deficient rats, evidenced by higher (
p
= 0.0058) mortality (72.0% vs. 32.1%). There was a temporal variation in heart rate and in the ratio of low- to high-frequency spectra, being higher (<0.001) during phase I, but lower (
p
< 0.05) during phase II in ETB-deficient rats. Likewise, 1 h post-MI, serum epinephrine (
p
= 0.025) and norepinephrine (
p
< 0.0001) were higher in ETB-deficient (4.20 ± 0.54, 14.24 ± 1.39 ng/ml) than in wild-type (2.30 ± 0.59, 5.26 ± 0.67 ng/ml) rats, respectively. After β-blockade, VT/VF episodes and mortality were similar in the two groups. The ETB-receptor decreases sympathetic activation and arrhythmogenesis during the early phase of MI, but these effects diminish during evolving MI.
Publisher
D. Steinkopff-Verlag,Springer Nature B.V
Subject
/ Adrenergic beta-Antagonists - therapeutic use
/ Animals
/ Medicine
/ Myocardial Infarction - complications
/ Myocardial Infarction - metabolism
/ Myocardial Infarction - pathology
/ Myocardial Infarction - physiopathology
/ Rats
/ Receptor, Endothelin B - genetics
/ Receptor, Endothelin B - metabolism
/ Tachycardia, Ventricular - etiology
/ Tachycardia, Ventricular - metabolism
/ Tachycardia, Ventricular - prevention & control
/ Ventricular Dysfunction, Left
/ Ventricular Fibrillation - etiology
