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MRI-guided clinical 6-MV radiosensitization of glioma using a unique gadolinium-based nanoparticles injection

by Lux, François , Verry, Camille , Le Duc, Géraldine , Balosso, Jacques , Dufort, Sandrine , Peoc'h, Michel , Chartier, Philippe , Tillement, Olivier , Sancey, Lucie , Barbier, Emmanuel Luc , Montigon, Olivier

in Animals / Bioengineering / Brain cancer / Brain research / Cancer / Cancer therapies / Chemotherapy / clinical 6-MV radiation therapy / Contrast agents / Contrast Media - administration & dosage / Contrast Media - chemistry / Disease Models, Animal / Drug dosages / Gadolinium - administration & dosage / Gadolinium - chemistry / Glioma / Glioma - diagnostic imaging / Glioma - pathology / Glioma - radiotherapy / Humans / Imaging / Life Sciences / Magnetic Resonance Imaging / Medical Physics / Melanoma / Metal Nanoparticles - administration & dosage / Metal Nanoparticles - chemistry / Metastasis / MRI-guided radiation therapy / Nanoparticles / Physics / Radiation therapy / Radiation-Sensitizing Agents - administration & dosage / Radiation-Sensitizing Agents - chemistry / radiosensitizing nanoparticles / Rats / Studies / Toxicology / Tumors / X-rays

2016

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MRI-guided clinical 6-MV radiosensitization of glioma using a unique gadolinium-based nanoparticles injection

2016

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MRI-guided clinical 6-MV radiosensitization of glioma using a unique gadolinium-based nanoparticles injection

2016

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Journal Article

MRI-guided clinical 6-MV radiosensitization of glioma using a unique gadolinium-based nanoparticles injection

Lux, François,

Verry, Camille,

Le Duc, Géraldine,

Balosso, Jacques,

Dufort, Sandrine,

Peoc'h, Michel,

Chartier, Philippe,

Tillement, Olivier,

Sancey, Lucie,

Barbier, Emmanuel Luc,

Montigon, Olivier

2016

Overview

This study reports the use of gadolinium-based AGuIX nanoparticles (NPs) as a theranostic tool for both image-guided radiation therapy and radiosensitization of brain tumors. Pharmacokinetics and regulatory toxicology investigations were performed on rodents. The AGuIX NPs' tumor accumulation was studied by MRI before 6-MV irradiation. AGuIX NPs exhibited a great safety profile. A single intravenous administration enabled the tumor delineation by MRI with a T tumor contrast enhancement up to 24 h, and the tumor volume reduction when combined with a clinical 6-MV radiotherapy. This study demonstrates the efficacy and the potential of AGuIX NPs for image-guided radiation therapy, promising properties that will be assessed in the upcoming Phase I clinical trial.

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Publisher

Future Medicine Ltd,Future Medicine

Subject

/ Cancer