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2-Guanidinobenzimidazole as Ligand in Supramolecular, Coordination and Organometallic Chemistry
2-Guanidinobenzimidazole as Ligand in Supramolecular, Coordination and Organometallic Chemistry
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2-Guanidinobenzimidazole as Ligand in Supramolecular, Coordination and Organometallic Chemistry
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2-Guanidinobenzimidazole as Ligand in Supramolecular, Coordination and Organometallic Chemistry
2-Guanidinobenzimidazole as Ligand in Supramolecular, Coordination and Organometallic Chemistry
Journal Article

2-Guanidinobenzimidazole as Ligand in Supramolecular, Coordination and Organometallic Chemistry

2025
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Overview
The benzimidazole core (BI) plays a central role in biologically active molecules. The BI nucleus is widely used as a building block to generate a variety of bioactive heterocyclic compounds to be used as antihelmintics, antiprotozoal, antimalarials, anti-inflammatories, antivirals, antimicrobials, antiparasitics, and antimycobacterials. A versatile BI derivative is the 2-guanidinobenzimidazole (2GBI), which, together with its derivatives, is a very interesting poly-functional planar molecule having a delocalised 10 π electrons system conjugated with the guanidine group. The 2GBI molecule has five nitrogen atoms containing five labile N–H bonds, which interact with the out-ward-facing channel entrance, forming a labile complex with the biological receptor sites. In this work, 2GBI and their derivatives were analyzed as ligands to form host–guest, coordination and organometallic complexes. Synthesis methodology, metal geometries, hydrogen bonding (HB) interactions, and the biological activities of the complexes were discussed.