Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Enhanced antipneumococcal antibody electrochemiluminescence assay: validation and bridging to the WHO reference ELISA

by Goldblatt, David , Zhang, Yuhua , Howlett, Adrienne H , Greway, Rebecca , de Gorguette d'Argoeuves, Polly , Murphy, Rocio D , Bonhomme, Cyrille J , Green, Tina , Nolan, Katrina M , Antonello, Joseph M

in Accuracy / Antibodies / Capsular polysaccharides / Clinical trials / electrochemiluminescence / ELISA / Enzyme-linked immunosorbent assay / Meso Scale Discovery / multiplex / optimization / Pediatrics / pneumococcal / Serotypes / Streptococcus infections / vaccine / Vaccines / validation

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Enhanced antipneumococcal antibody electrochemiluminescence assay: validation and bridging to the WHO reference ELISA

2020

Confirm

Do you wish to request the book?

Enhanced antipneumococcal antibody electrochemiluminescence assay: validation and bridging to the WHO reference ELISA

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Enhanced antipneumococcal antibody electrochemiluminescence assay: validation and bridging to the WHO reference ELISA

Goldblatt, David,

Zhang, Yuhua,

Howlett, Adrienne H,

Greway, Rebecca,

de Gorguette d'Argoeuves, Polly,

Murphy, Rocio D,

Bonhomme, Cyrille J,

Green, Tina,

Nolan, Katrina M,

Antonello, Joseph M

2020

Overview

To re-optimize the pneumococcal (Pn) electrochemiluminescence (ECL) assay and to validate and bridge the enhanced assay to the WHO ELISA, to support the Phase III clinical trial program for V114, a 15-valent Pn conjugate vaccine. The Pn ECL assay was re-optimized, validated and formally bridged to the WHO ELISA. The enhanced Pn ECL assay met all prespecified validation acceptance criteria and demonstrated concordance with the WHO ELISA. The corresponding threshold value remains at 0.35 μg/ml for all 15 serotypes. The enhanced Pn ECL assay has been validated for the measurement of antibodies to 15 Pn capsular polysaccharides and is concordant with the WHO ELISA, supporting its use in clinical trials.

Share this book

Add to My Shelf

Publisher

Newlands Press Ltd,Newlands Press

Subject

Accuracy

/ Antibodies

/ Capsular polysaccharides

/ Clinical trials

/ electrochemiluminescence

/ ELISA

/ Enzyme-linked immunosorbent assay