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Structure of neprilysin in complex with the active metabolite of sacubitril
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Structure of neprilysin in complex with the active metabolite of sacubitril
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Structure of neprilysin in complex with the active metabolite of sacubitril
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Journal Article
Structure of neprilysin in complex with the active metabolite of sacubitril
2016
Overview
Sacubitril is an ethyl ester prodrug of LBQ657, the active neprilysin (NEP) inhibitor and a component of LCZ696 (sacubitril/valsartan). We report herein the three-dimensional structure of LBQ657 in complex with human NEP at 2 Å resolution. The crystal structure unravels the binding mode of the compound occupying the S1, S1’ and S2’ sub-pockets of the active site, consistent with a competitive inhibition mode. An induced fit conformational change upon binding of the P1’-biphenyl moiety of the inhibitor suggests an explanation for its selectivity against structurally homologous zinc metallopeptidases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
