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The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses
by
Saleh, Saleh A. K.
, Adi, Abdul Rahman
, Al-Agsam, Marwah Ali Mohammed
, Al Shaikh, Mona Ahmed
, Alharran, Abdullah M.
, Alshammari, Nawal
, Abu-Zaid, Ahmed
, Adly, Heba M.
, Kutbi, Emad
, Albahrani, Suha Jafar
in
Adipose Tissue - drug effects
/ Anthropometry
/ Body fat
/ Body Mass Index
/ Body weight
/ Body Weight - drug effects
/ Clinical trials
/ Diabetes
/ Dietary Supplements
/ Fatty liver
/ Humans
/ Intervention
/ Liver diseases
/ Medicine
/ Medicine & Public Health
/ Meta-analysis
/ Meta-Analysis as Topic
/ Metabolism
/ Obesity
/ Obesity - drug therapy
/ Ovaries
/ Overweight
/ Polycystic ovary syndrome
/ Psychiatry
/ Questionnaires
/ Resveratrol
/ Resveratrol - pharmacology
/ Resveratrol - therapeutic use
/ Review
/ Statistical analysis
/ Systematic review
/ Umbrella of meta-analysis
/ Waist Circumference - drug effects
2025
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The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses
by
Saleh, Saleh A. K.
, Adi, Abdul Rahman
, Al-Agsam, Marwah Ali Mohammed
, Al Shaikh, Mona Ahmed
, Alharran, Abdullah M.
, Alshammari, Nawal
, Abu-Zaid, Ahmed
, Adly, Heba M.
, Kutbi, Emad
, Albahrani, Suha Jafar
in
Adipose Tissue - drug effects
/ Anthropometry
/ Body fat
/ Body Mass Index
/ Body weight
/ Body Weight - drug effects
/ Clinical trials
/ Diabetes
/ Dietary Supplements
/ Fatty liver
/ Humans
/ Intervention
/ Liver diseases
/ Medicine
/ Medicine & Public Health
/ Meta-analysis
/ Meta-Analysis as Topic
/ Metabolism
/ Obesity
/ Obesity - drug therapy
/ Ovaries
/ Overweight
/ Polycystic ovary syndrome
/ Psychiatry
/ Questionnaires
/ Resveratrol
/ Resveratrol - pharmacology
/ Resveratrol - therapeutic use
/ Review
/ Statistical analysis
/ Systematic review
/ Umbrella of meta-analysis
/ Waist Circumference - drug effects
2025
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The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses
by
Saleh, Saleh A. K.
, Adi, Abdul Rahman
, Al-Agsam, Marwah Ali Mohammed
, Al Shaikh, Mona Ahmed
, Alharran, Abdullah M.
, Alshammari, Nawal
, Abu-Zaid, Ahmed
, Adly, Heba M.
, Kutbi, Emad
, Albahrani, Suha Jafar
in
Adipose Tissue - drug effects
/ Anthropometry
/ Body fat
/ Body Mass Index
/ Body weight
/ Body Weight - drug effects
/ Clinical trials
/ Diabetes
/ Dietary Supplements
/ Fatty liver
/ Humans
/ Intervention
/ Liver diseases
/ Medicine
/ Medicine & Public Health
/ Meta-analysis
/ Meta-Analysis as Topic
/ Metabolism
/ Obesity
/ Obesity - drug therapy
/ Ovaries
/ Overweight
/ Polycystic ovary syndrome
/ Psychiatry
/ Questionnaires
/ Resveratrol
/ Resveratrol - pharmacology
/ Resveratrol - therapeutic use
/ Review
/ Statistical analysis
/ Systematic review
/ Umbrella of meta-analysis
/ Waist Circumference - drug effects
2025
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The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses
Journal Article
The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses
2025
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Overview
Objective
Despite several studies assessing the impact of resveratrol on obesity indices, previous meta-analyses show conflicting results. Therefore, we conducted this critical umbrella review of interventional meta-analyses on the effect of resveratrol supplementation on body mass index (BMI), body weight (BW), waist circumference (WC), and body fat.
Methods
Searches were conducted across multiple databases to identify all relevant meta-analyses up to September 30th, 2025. Reported pooled effect sizes (ESs) and 95% confidence intervals (CIs) were extracted from each included study and synthesized using a random-effects model. Methodological quality was assessed using the AMSTAR 2 tool.
Results
Ultimately, 18 meta-analyses were included, with results showing a small but statistically significant reduction in BW (ES: − 0.18 kg, 95% CI − 0.32 to − 0.03,
p
= 0.02), BMI (ES: − 0.14 kg/m
2
, 95% CI − 0.2 to − 0.08,
p
< 0.001), WC (ES − 0.43 cm, 95% CI − 0.64 to − 0.22,
p
< 0.001), and body fat (ES: − 0.3 kg, 95% CI − 0.48 to − 0.12,
p
= 0.001) in the resveratrol group compared to the control group, with subgroup analysis revealing statistical significance only in subgroups with doses > 400 mg/day and study duration ˃ 12 weeks.
Conclusion
Our review confirms that resveratrol supplementation reduces BW, BMI, WC, and body fat, particularly on doses > 400 mg/day and interventions lasting ˃12 weeks, with small effect sizes. Based on our findings, resveratrol supplementation could be considered as a complementary therapy in the management of obesity.
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