Asset Details
Do you wish to reserve the book?
Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children
Do you wish to request the book?
Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children
2014
Overview
Increasing evidence suggests that altered intestinal microbial composition and function result in an increased risk of
Clostridium difficile
-associated diarrhoea (CDAD); however, the specific changes of intestinal microbiota in children suffering from CDAD and their associations with
C.
difficile
strain toxigenicity are poorly understood. High-throughput pyrosequencing showed that reduced faecal bacterial diversity and dramatic shifts of microbial composition were found in children with CDAD. The Firmicutes/Bacteroidetes ratio was increased significantly in patients with CDAD, which indicated that dysbiosis of faecal microbiota was closely associated with CDAD.
C. difficile
infection resulted in an increase in lactate-producing phylotypes, with a corresponding decrease in butyrate-producing bacteria. The decrease in butyrate and lactate buildup impaired intestinal colonisation resistance, which increased the susceptibility to
C. difficile
colonisation. Strains of
C.
difficile
which were positive for both toxin A and toxin B reduced faecal bacterial diversity to a greater degree than strains that were only toxin B-positive and were associated with unusually abundant
Enterococcus
, which implies that the
C. difficile
toxins have different impacts on the faecal microbiota of children. Greater understanding of the relationships between disruption of the normal faecal microbiota and colonisation with
C. difficile
that produces different toxins might lead to improved treatment.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/23
/ Bacterial Toxins - isolation & purification
/ Children
/ Diarrhea
/ Enterocolitis, Pseudomembranous - microbiology
/ Enterocolitis, Pseudomembranous - physiopathology
/ Enterocolitis, Pseudomembranous - transmission
/ Humanities and Social Sciences
/ Humans
/ Real-Time Polymerase Chain Reaction
/ RNA, Ribosomal, 16S - genetics
/ Science
/ Toxin A
/ Toxin B
/ Toxins
