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Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases
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Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases
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Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases
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Journal Article
Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases
2013
Overview
Objective
To determine the measurement reproducibility of perfusion fraction
f
, pseudodiffusion coefficient
D
*
and diffusion coefficient
D
in colorectal liver metastases and normal liver.
Methods
Fourteen patients with known colorectal liver metastases were examined twice using respiratory-triggered echo-planar DW-MRI with eight
b
values (0 to 900 s/mm
2
) 1 h apart. Regions of interests were drawn around target metastasis and normal liver in each patient to derive ADC (all
b
values), ADC
high
(
b
values ≥100 s/mm
2
) and intravoxel incoherent motion (IVIM) parameters
f
,
D
*
and
D
by least squares data fitting. Short-term measurement reproducibility of median ADC, ADC
high
,
f
,
D
*
and
D
values were derived from Bland–Altman analysis.
Results
The measurement reproducibility for ADC, ADC
high
and
D
was worst in colorectal liver metastases (−21 % to +25 %) compared with liver parenchyma (−6 % to +8 %). Poor measurement reproducibility was observed for the perfusion-sensitive parameters of
f
(−75 % to +241 %) and
D
*
(−89 % to +2,120 %) in metastases, and to a lesser extent the
f
(−24 % to +25 %) and
D*
(−31 % to +59 %) of liver.
Conclusions
Estimates of
f
and
D
*
derived from the widely used least squares IVIM fitting showed poor measurement reproducibility. Efforts should be made to improve the measurement reproducibility of perfusion-sensitive IVIM parameters.
Key Points
•
Quantitative diffusion-weighted MRI parameters are increasingly used for clinical management decisions.
•
However perfusion-sensitive intravoxel incoherent motion (IVIM) parameters showed poor measurement reproducibility.
•
Measurement reproducibility of IVIM parameters was worse in metastases than normal liver.
•
Efforts to improve measurement reproducibility of IVIM parameters should be explored.
Publisher
Springer-Verlag,Springer Nature B.V
