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The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
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The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
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Journal Article
The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis
2015
Overview
Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from
IL4
gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29–2.14]). We also detected an association of
TLR2
gene with tuberculosis (rs5743708; 3.19 [2.03–5.02]). Subset analyses identified
CCL2
as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72–0.88]). The
IL4
-
TLR2
-
CCL2
axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 49/22
/ 692/4017
/ Humanities and Social Sciences
/ Humans
/ Monocyte chemoattractant protein 1
/ Polymorphism, Single Nucleotide
/ Respiratory Tract Infections - genetics
/ Respiratory Tract Infections - metabolism
/ Respiratory Tract Infections - pathology
/ Science
/ Single-nucleotide polymorphism
/ Studies
