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Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer’s mice model
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Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer’s mice model
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Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer’s mice model
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Journal Article
Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer’s mice model
2025
Overview
Alzheimer’s disease (AD) is responsible for more than 80% of cases of dementia in senior individuals globally. In the current study, the role of modulation of the FGF1/PI3K/Akt pathway in the protective effect of tozasertib was evaluated. Experimental dementia was induced in mice by injecting streptozotocin (STZ) intracerebroventricularly. Various biochemical parameters for oxidative stress & lipid peroxidation (SOD, GSH, catalase, TBARS), neuroinflammation (MPO, IL-6, IL-1 β, TNF-α, NFκB), apoptotic markers (Bax, Bcl-2, Caspase-3), and memory parameters (AChE activity, β1–40 levels) were assessed. The behavioral parameters evaluated included the Morris Water Maze test and the step-down passive avoidance test. Histological changes were assessed using H&E staining. ICV STZ-induced AD resulted in increased oxidative stress, lipid peroxidation, neuroinflammation, apoptosis, and decreased learning and memory. The results showed that administration of tozasertib improved memory, decreased levels of oxidative stress, inflammatory parameters, and apoptotic markers, and improved histological parameters in a dose-dependent manner. Pre-administration of LY294002, a PI3K/Akt pathway inhibitor, partially reversed the protective effects of Tozasertib, suggesting possible involvement of this pathway. However, as the mechanism was inferred primarily through pharmacological antagonism, further studies including direct molecular assessments (e.g. p-Akt/t-Akt) are warranted to confirm the role of FGF1/PI3K/Akt signaling in Tozasertib’s action.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
1-Phosphatidylinositol 3-kinase
/ 631/378
/ 631/45
/ Alzheimer Disease - chemically induced
/ Alzheimer Disease - drug therapy
/ Alzheimer Disease - metabolism
/ Alzheimer Disease - pathology
/ Animals
/ Brain
/ Dementia
/ Fibroblast Growth Factor 1 - metabolism
/ Humanities and Social Sciences
/ Kinases
/ Lipid Peroxidation - drug effects
/ Male
/ Maze Learning - drug effects
/ Memory
/ Mice
/ Neuroprotective Agents - pharmacology
/ Neuroprotective Agents - therapeutic use
/ Oxidative Stress - drug effects
/ Phosphatidylinositol 3-Kinases - metabolism
/ Proto-Oncogene Proteins c-akt - metabolism
/ Science
