Journal Article

MRI predictors of clinical success in MR-guided focused ultrasound (MRgFUS) treatments of uterine fibroids: results from a single centre

Herzog, Peter, Mindjuk, Irene, Stahl, Robert, Trumm, Christoph G., Matzko, Matthias

2015

Overview

Objectives To assess the technical and clinical results of MRgFUS treatment and factors affecting clinical treatment success. Materials and methods A total of 252 women (mean age, 42.1 ± 6.9 years) with uterine fibroids underwent MRgFUS. All patients underwent MRI before treatment. Results were evaluated with respect to post-treatment nonperfused volume (NPV), symptom severity score (SSS), reintervention rate, pregnancy and safety data. Results NPV ratio was significantly higher in fibroids characterized by low signal intensity in contrast-enhanced T1-weighted fat saturated MR images and in fibroids distant from the spine (>3 cm). NPV ratio was lower in fibroids with septations, with subserosal component and in skin-distant fibroids ( p  < 0.001). NPV ratio was highly correlated with clinical success: NPV of more than 80 % resulted in clinical success in more than 80 % of patients. Reintervention rate was 12.7 % (mean follow-up time, 19.4 ± 8 months; range, 3–38). Expulsion of fibroids (21 %) was significantly correlated with a high clinical success rate. No severe adverse events were reported. Conclusions Adequate patient selection and correct treatment techniques, based on the learning curve of this technology, combined with technical advances of the system, lead to higher clinical success rates with low complications rate, comparable to other uterine-sparing treatment options. Key Points • MRgFUS appears to be a valid alternative to other uterus-preserving therapies • Patient selection is a significant factor in achieving high NPV ratios • MRI screening parameters correlate with the amount of fibroid ablation in MRgFUS • NPV results of more than 80 % correlate with higher clinical success rates

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Ablation / Adult / Clinical outcomes / Contrast Media / Diagnostic Radiology / Embolization / Female / Fibroids / Gadolinium / High-Intensity Focused Ultrasound Ablation - methods / Humans / Image Enhancement / Imaging / Internal Medicine / Interventional / Interventional Radiology / Leiomyoma - surgery / Magnetic resonance imaging / Magnetic Resonance Imaging, Interventional - methods / Medicine / Medicine & Public Health / Neuroradiology / Nuclear polyhedrosis virus / Patients / Radiology / Success / Treatment Outcome / Ultrasonic imaging / Ultrasound / Uterine Neoplasms - surgery / Uterus