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More than apples and oranges - Detecting cancer with a fruit fly's antenna

by Laudes, Thomas , Lüdke, Alja , Paolesse, Roberto , Ulivieri, Alessandra , Capuano, Rosamaria , Galizia, C. Giovanni , Martinelli, Eugenio , Di Natale, Corrado , Strauch, Martin , Münch, Daniel , Lavra, Luca , Catini, Alexandro

in 13/106 / 14/19 / 631/1647/245/2226 / 631/378/2624/2625 / 631/67/1347 / 64/24 / Animals / Antennae / Arthropod Antennae - physiology / Breast cancer / Calcium imaging / Cancer / Drosophila melanogaster - physiology / Electronic noses / Epithelial cells / Fruits / Humanities and Social Sciences / Humans / Mammary gland / multidisciplinary / Neoplasms - chemistry / Neoplasms - diagnosis / Odorant receptors / Odorants / Olfaction / Olfactory receptor neurons / Olfactory Receptor Neurons - physiology / Olfactory system / Receptive field / Science / Sensors / Smell / Volatile compounds / Volatile Organic Compounds - analysis

2014

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2014

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2014

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Journal Article

More than apples and oranges - Detecting cancer with a fruit fly's antenna

Laudes, Thomas,

Lüdke, Alja,

Paolesse, Roberto,

Ulivieri, Alessandra,

Capuano, Rosamaria,

Galizia, C. Giovanni,

Martinelli, Eugenio,

Di Natale, Corrado,

Strauch, Martin,

Münch, Daniel,

Lavra, Luca,

Catini, Alexandro

2014

Overview

Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated the potential of utilising the fruit fly's olfactory system to detect cancer cells. Using in vivo calcium imaging, we recorded an array of olfactory receptor neurons on the fruit fly's antenna. We performed multidimensional analysis of antenna responses, finding that cell volatiles from different cell types lead to characteristic response vectors. The distances between these response vectors are conserved across flies and can be used to discriminate healthy mammary epithelial cells from different types of breast cancer cells. This may expand the repertoire of clinical diagnostics and it is the first step towards electronic noses equipped with biological sensors, integrating artificial and biological olfaction.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 14/19

/ 64/24

/ Animals