Asset Details
Do you wish to reserve the book?
Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration
Do you wish to request the book?
Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration
2017
Overview
Age-related macular degeneration (AMD) is the most frequent cause of blindness in the elderly. There is evidence that nutrition, inflammation and genetic risk factors play an important role in the development of AMD. Recent studies suggest that the composition of the intestinal microbiome is associated with metabolic diseases through modulation of inflammation and host metabolism. To investigate whether compositional and functional alterations of the intestinal microbiome are associated with AMD, we sequenced the gut metagenomes of patients with AMD and controls. The genera
Anaerotruncus
and
Oscillibacter
as well as
Ruminococcus torques
and
Eubacterium ventriosum
were relatively enriched in patients with AMD, whereas
Bacteroides eggerthii
was enriched in controls. Patient’s intestinal microbiomes were enriched in genes of the L-alanine fermentation, glutamate degradation and arginine biosynthesis pathways and decreased in genes of the fatty acid elongation pathway. These findings suggest that modifications in the intestinal microbiome are associated with AMD, inferring that this common sight threatening disease may be targeted by microbiome-altering interventions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
