Journal Article

Endovascular treatment of brain arteriovenous malformations using a liquid embolic agent: results of a prospective, multicentre study (BRAVO)

Pierot, L., Beltramello, A., Kupcs, K., Reith, W., Sourour, N., Cognard, C., Fransen, H., Bonafé, A., Boccardi, E., van Rooij, W. J., Herbreteau, D., Biondi, A., Casasco, A.

2013

Overview

Objectives To evaluate the safety and efficacy of a new liquid embolic agent in brain arteriovenous malformation (bAVMs) embolisation. Methods A prospective, multicentre series was conducted at 11 interventional centres in Europe to evaluate embolisation of bAVMs with the new liquid embolic agent. Technical conditions, complications, clinical outcome and anatomical results were independently analysed. Results From December 2005 to December 2008, 117 patients (72 male; 45 female, aged 18–75 years) were included. Clinical presentation was mostly haemorrhage (34.2 %) and seizures (28.2 %). Most AVMs were located in the brain hemispheres (85.5 %). AVMs were <3 cm in 52.1 % of patients and ≥3 cm in 47.9 %. Morbidity was observed in 6/117 patients (5.1 %), related to haemorrhagic events in 2 cases and non-haemorrhagic complications in 4 cases. Five patients (4.3 %) died in relation to the treatment (bleeding in 4 patients and extensive venous thrombosis in 1). Complete occlusion of the AVM by embolisation alone was obtained in 23.5 % of patients. Complementary treatment was performed in 82.3 % of patients with partial AVM occlusion, mostly radiosurgery. Conclusions In this prospective, multicentre, European, observational series, the new liquid embolic agent proved to be suitable for BAVM embolisation, with acceptable morbidity and mortality and good efficacy. Key Points • Numerous interventional techniques have been used to embolise brain arteriovenous malformations (AVMs). • This prospective multicentre study demonstrates the suitability of a liquid embolic agent. • The safety of treatment using Onyx is acceptable. • Such embolisation leads to complete AVM occlusion in 23.5 % of patients.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adolescent / Adult / Aged / Aged, 80 and over / Arteriovenous Fistula - diagnostic imaging / Arteriovenous Fistula - epidemiology / Arteriovenous Fistula - therapy / Diagnostic Radiology / Dimethyl Sulfoxide - therapeutic use / Embolization / Embolization, Therapeutic - methods / Embolization, Therapeutic - statistics & numerical data / Europe - epidemiology / Female / Hemostatics - therapeutic use / Humans / Imaging / Internal Medicine / Interventional Radiology / Intracranial Arteriovenous Malformations - diagnostic imaging / Intracranial Arteriovenous Malformations - epidemiology / Intracranial Arteriovenous Malformations - therapy / Male / Medicine / Medicine & Public Health / Middle Aged / Morbidity / Mortality / Neuro / Neuroradiology / Polyvinyls - therapeutic use / Prevalence / Prospective Studies / Radiography / Radiology / Radiosurgery / Risk Factors / Treatment Outcome / Ultrasound / Young Adult