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Synthesis and biological evaluation of (±)-hippolachnin and analogs
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Synthesis and biological evaluation of (±)-hippolachnin and analogs
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Journal Article
Synthesis and biological evaluation of (±)-hippolachnin and analogs
2019
Overview
Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.
Publisher
Nature Publishing Group
Subject
