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Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
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Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
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Journal Article
Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
2014
Overview
Clostridium difficile infection is the main cause of healthcareacquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence.
Publisher
Oxford University Press
Subject
ADP Ribose Transferases - genetics
/ ADP Ribose Transferases - physiology
/ Animals
/ BACTERIA
/ Bacterial Proteins - genetics
/ Bacterial Proteins - physiology
/ Biological and medical sciences
/ Clostridioides difficile - genetics
/ Clostridioides difficile - pathogenicity
/ Clostridium Infections - microbiology
/ Clostridium Infections - pathology
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Toxins
