Journal Article

Maternal consumption of quinine-containing sodas may induce G6PD crises in breastfed children

Vauzelle, C, Department of Pediatric Intensive Care ; Erasmus University Medical Center [Rotterdam] (Erasmus MC), Cortey, A, Leverger, G, Deslandes, G, Bichali, S, Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] (CH Argenteuil), Bosher, C, Chenouard, A, CHU Henri Mondor [Créteil], Brault, D, Elephant, E, CHU Trousseau [APHP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Pissard, S, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Rozé, Jean-Christophe, Masserot, C, Couec, Marie-Laure

2017

Overview

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect often presenting with neonatal jaundice and/or hemolytic anemia. G6PD hemolytic events are linked with exposure to a pro-oxidant agent. We here report three cases of initial G6PD crises in breastfed children secondary to maternal consumption of a tonic drink which contains quinine. Quinine was found in breast milk of one of the mothers after she consumed tonic water. CONCLUSION: The amount of quinine that is transmitted through breast milk appears to be sufficient to induce G6PD crises in breastfed children. We hence recommend that consumption of quinine-containing sodas during breastfeeding should be avoided in populations with a high prevalence of G6PD deficiency. What is Known: • G6PD hemolytic events are linked with exposure to a pro-oxidant agent. • Ingestion of fava beans by a mother who was breastfeeding has been reported to induce a neonatal G6PD crisis. What is New: • Maternal consumption of tonic drink which contains quinine appears to be sufficient to induce G6PD crises in breastfed children. • Maternal consumption of quinine-containing sodas during breastfeeding should be avoided in populations with a high prevalence of G6PD deficiency.

• Publisher: Springer Verlag [1975-....],CCSD,Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Anemia / Baby foods / Breast Feeding / Breast milk / Breastfeeding & lactation / Carbonated Beverages - toxicity / Children / Female / Food and Nutrition / Glucosephosphate dehydrogenase / Glucosephosphate Dehydrogenase Deficiency - chemically induced / Glucosephosphate Dehydrogenase Deficiency - diagnosis / Hemolytic anemia / Humans / Infant / Infant, Newborn / Jaundice / Life Sciences / Male / Medicine / Medicine & Public Health / Milk / Neonates / Oxidants - toxicity / Pediatrics / Quinine / Quinine - toxicity / Short Communication