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A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy (MBT-T) in Breast Cancer Patients: Preliminary Results

by Celia, Giovanna , Budillon, Alfredo , De Laurentiis, Michelino , Madonna, Gabriele , Cavicchiolo, Elisa , Girelli, Laura , Piezzo, Michela , Costantini, Susan , Barberio, Daniela , Cocco, Stefania , Ascierto, Paolo Antonio , Abate, Valentina , Capone, Francesca , Cozzolino, Mauro

in Apoptosis / Breast cancer / Cancer therapies / Chemokines / Chronic illnesses / Clinical medicine / Cytokines / Disease / Gene expression / Genomics / Growth factors / Inflammation / Medical prognosis / Metastasis / Physiology / Signal transduction / Stress / Tumors / Womens health

2021

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Journal Article

A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy (MBT-T) in Breast Cancer Patients: Preliminary Results

Celia, Giovanna,

Budillon, Alfredo,

De Laurentiis, Michelino,

Madonna, Gabriele,

Cavicchiolo, Elisa,

Girelli, Laura,

Piezzo, Michela,

Costantini, Susan,

Barberio, Daniela,

Cocco, Stefania,

Ascierto, Paolo Antonio,

Abate, Valentina,

Capone, Francesca,

Cozzolino, Mauro

2021

Overview

Several studies have highlighted the key role of chronic inflammation in breast cancer development, progression, metastasis, and therapeutic outcome. These processes are mediated through a variety of cytokines and hormones that exert their biological actions either locally or distantly via systemic circulation. Recent findings suggest that positive psychosocial experiences, including psychotherapeutic interventions and therapeutic mind-body protocols, can modulate the inflammatory response by reducing the expression of genes/proteins associated with inflammation and stress-related pathways. Our preliminary results indicate that a specific mind-body therapy (MBT-T) could induce a significant reduction of the release of different cytokines and chemokines, such as SCGFβ, SDF-1α, MCP3, GROα, LIF, and IL-18, in the sera of breast cancer patients compared to a control group, suggesting that MBT-T could represent a promising approach to improve the wellness and outcome of breast cancer patients.

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MDPI AG,MDPI

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